Blood levels of heavy metals and metallothionein in type 2
diabetics with kidney disease

a 2013

Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease

PÁCAL, Lukáš; Veronika DVOŘÁKOVÁ; Martina RAUDENSKÁ; Katarína KURICOVÁ; Jaromír GUMULEC et al.

Základní údaje

Originální název

Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease

Autoři

Vydání

Diabetes - a Threat to Mankind, 2013

Další údaje

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Změněno: 13. 6. 2013 10:20, Mgr. Lukáš Pácal, Ph.D.

Anotace

V originále

Oxidative stress and subsequent activation of antioxidant mechanisms (both enzymatic and nonenzymatic) is well established in type 2 diabetes (T2DM). Metallothionein (MT) is a protein binding heavy metal ions (primarily zinc). MT substantially affects zinc metabolism and thus insulin secretion by beta-cell. Zinc levels are often decreased in diabetics due to its increased renal clearance. Association of polymorphism in the gene for zinc transporter (ZnT-8) with T2DM in genome wide association study (Sladek R et al. Nature 2007) underlines the role of zinc for glucose metabolism. We aimed to determine blood levels of selected heavy metals, MT, antioxidants and relevant SNPs in type 2 diabetics with kidney disease (at least microalbuminuric) and healthy subjects.

Návaznosti

NT13198, projekt VaV

Název: Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Investor: Ministerstvo zdravotnictví ČR, Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Citovat

PÁCAL, Lukáš; Veronika DVOŘÁKOVÁ; Martina RAUDENSKÁ; Katarína KURICOVÁ; Jaromír GUMULEC; Jan SVOJANOVSKÝ; Jitka ŘEHOŘOVÁ; Branislav RUTTKAY-NEDECKÝ; Ondřej ZÍTKA; René KIZEK; Michal MASAŘÍK a Kateřina KAŇKOVÁ. Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease. In Diabetes - a Threat to Mankind. 2013.

@proceedings{1111186,
   author = {Pácal, Lukáš and Dvořáková, Veronika and Raudenská, Martina and Kuricová, Katarína and Gumulec, Jaromír and Svojanovský, Jan and Řehořová, Jitka and RuttkayandNedecký, Branislav and Zítka, Ondřej and Kizek, René and Masařík, Michal and Kaňková, Kateřina},
   booktitle = {Diabetes - a Threat to Mankind},
   title = {Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease},
   year = {2013}
}

TY  - CONF
ID  - 1111186
AU  - Pácal, Lukáš - Dvořáková, Veronika - Raudenská, Martina - Kuricová, Katarína - Gumulec, Jaromír - Svojanovský, Jan - Řehořová, Jitka - Ruttkay-Nedecký, Branislav - Zítka, Ondřej - Kizek, René - Masařík, Michal - Kaňková, Kateřina
PY  - 2013
TI  - Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease
N2  - Oxidative stress and subsequent activation of antioxidant mechanisms (both enzymatic and nonenzymatic) is well established in type 2 diabetes (T2DM). Metallothionein (MT) is a protein binding heavy metal ions (primarily zinc). MT substantially affects zinc metabolism and thus insulin secretion by beta-cell. Zinc levels are often decreased in diabetics due to its increased renal clearance. Association of polymorphism in the gene for zinc transporter (ZnT-8) with T2DM in genome wide association study (Sladek R et al. Nature 2007) underlines the role of zinc for glucose metabolism. We aimed to determine blood levels of selected heavy metals, MT, antioxidants and relevant SNPs in type 2 diabetics with kidney disease (at least microalbuminuric) and healthy subjects.
ER  -

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