Polymorphisms in HLA-related genes and psoriasis heredity in
patients with psoriasis

J 2013

Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Lydie IZAKOVIČOVÁ HOLLÁ; Monika PÁVKOVÁ GOLDBERGOVÁ; Zuzana KOZÁČIKOVÁ et al.

Základní údaje

Originální název

Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

Autoři

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Lydie IZAKOVIČOVÁ HOLLÁ; Monika PÁVKOVÁ GOLDBERGOVÁ; Zuzana KOZÁČIKOVÁ; Zbyněk ŠPLÍCHAL a Vladimír VAŠKŮ

Vydání

International Journal of Dermatology, USA, Wiley-Blackwell, 2013, 0011-9059

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.227

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00069381

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/ijd.12213

UT WoS

000322015000009

Klíčová slova anglicky

MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II REGION; HAPLOTYPE RECONSTRUCTION; MEIOTIC RECOMBINATION; POPULATION; SUSCEPTIBILITY; VULGARIS; ASSOCIATION; LOCUS

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 3. 2014 10:08, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.

Citovat

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Lydie IZAKOVIČOVÁ HOLLÁ; Monika PÁVKOVÁ GOLDBERGOVÁ; Zuzana KOZÁČIKOVÁ; Zbyněk ŠPLÍCHAL a Vladimír VAŠKŮ. Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis. International Journal of Dermatology. USA: Wiley-Blackwell, 2013, roč. 52, č. 8, s. 960-965. ISSN 0011-9059. Dostupné z: https://doi.org/10.1111/ijd.12213.

@article{1122872,
   author = {Vašků, Anna and Bienertová Vašků, Julie and Izakovičová Hollá, Lydie and Pávková Goldbergová, Monika and Kozáčiková, Zuzana and Šplíchal, Zbyněk and Vašků, Vladimír},
   article_location = {USA},
   article_number = {8},
   doi = {https://doi.org/10.1111/ijd.12213},
   keywords = {MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II REGION; HAPLOTYPE RECONSTRUCTION; MEIOTIC RECOMBINATION; POPULATION; SUSCEPTIBILITY; VULGARIS; ASSOCIATION; LOCUS},
   language = {eng},
   issn = {0011-9059},
   journal = {International Journal of Dermatology},
   title = {Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis},
   volume = {52},
   year = {2013}
}

TY  - JOUR
ID  - 1122872
AU  - Vašků, Anna - Bienertová Vašků, Julie - Izakovičová Hollá, Lydie - Pávková Goldbergová, Monika - Kozáčiková, Zuzana - Šplíchal, Zbyněk - Vašků, Vladimír
PY  - 2013
TI  - Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis
JF  - International Journal of Dermatology
VL  - 52
IS  - 8
SP  - 960-965
EP  - 960-965
PB  - Wiley-Blackwell
SN  - 00119059
KW  - MAJOR HISTOCOMPATIBILITY COMPLEX
KW  - CLASS-II REGION
KW  - HAPLOTYPE RECONSTRUCTION
KW  - MEIOTIC RECOMBINATION
KW  - POPULATION
KW  - SUSCEPTIBILITY
KW  - VULGARIS
KW  - ASSOCIATION
KW  - LOCUS
N2  - Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.
ER  -

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Lydie IZAKOVIČOVÁ HOLLÁ; Monika PÁVKOVÁ GOLDBERGOVÁ; Zuzana KOZÁČIKOVÁ; Zbyněk ŠPLÍCHAL a Vladimír VAŠKŮ. Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis. \textit{International Journal of Dermatology}. USA: Wiley-Blackwell, 2013, roč.~52, č.~8, s.~960-965. ISSN~0011-9059. Dostupné z: https://doi.org/10.1111/ijd.12213.

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