PŘIKRYL, Radovan, Libor USTOHAL, Hana PŘIKRYLOVÁ KUČEROVÁ, Tomáš KAŠPÁREK, Simona VENCLÍKOVÁ, Michaela MAYEROVÁ a Eva ČEŠKOVÁ. A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial. Schizophrenia Research, Amserdam: Elsevier Science, 2013, roč. 149, 1-3, s. 167-173. ISSN 0920-9964. doi:10.1016/j.schres.2013.06.015.
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Základní údaje
Originální název A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial
Autoři PŘIKRYL, Radovan (203 Česko, garant, domácí), Libor USTOHAL (203 Česko, domácí), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Česko, domácí), Tomáš KAŠPÁREK (203 Česko, domácí), Simona VENCLÍKOVÁ (203 Česko, domácí), Michaela MAYEROVÁ (203 Česko, domácí) a Eva ČEŠKOVÁ (203 Česko, domácí).
Vydání Schizophrenia Research, Amserdam, Elsevier Science, 2013, 0920-9964.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 4.426
Kód RIV RIV/00216224:14740/13:00069546
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1016/j.schres.2013.06.015
UT WoS 000323937200026
Klíčová slova anglicky High-frequency; Negative symptoms; Prefrontal cortex; Repetitive transcranial magnetic stimulation; rTMS; SANS
Štítky ok, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Olga Křížová, učo 56639. Změněno: 4. 4. 2014 08:46.
Anotace
Objective The aim of the study was to assess the effect of rTMS not only on the general severity of negative schizophrenia symptoms, but also particularly on their individual domains, such as affective flattening or blunting, alogia, avolition or apathy, anhedonia, and impaired attention. Methods Forty schizophrenic male patients on stable antipsychotic medication with prominent negative symptoms were included in the study. They were divided into two groups: 23 were treated with active and 17 with placebo rTMS. Both treatments were similar, but placebo rTMS was administered using a purpose-built sham coil. Stimulation was applied to the left dorsolateral prefrontal cortex (DLPFC). The stimulation frequency was 10 Hz; stimulation intensity was 110% of the individual motor threshold intensity. Each patient received 15 rTMS sessions on 15 consecutive working days (five working days “on” and two weekend days “off” design). Each daily session consisted of 20 applications of 10-second duration with 30-second intervals between sequences. The patients and raters were blind to condition of stimulation treatment. Results The active rTMS led to a statistically significantly higher reduction of the Scale for the Assessment of Negative Symptoms (SANS) total score and of all domains of negative symptoms of schizophrenia. After Bonferroni adjustments for multiple testing, the statistical significance disappeared in alogia only. Conclusion High-frequency rTMS stimulation over the left DLPFC at a high stimulation intensity with a sufficient number of applied stimulating pulses may represent an efficient augmentation of antipsychotics in alleviating the negative symptoms of schizophrenia.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
VytisknoutZobrazeno: 3. 7. 2020 22:36