| MATULKA, Kamil, Hsuan-hwai LIN, Hana HŘÍBKOVÁ, Dafe UWANOGHO, Petr DVOŘÁK a Yuh-Man SUN. PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells. Cell stem cell. Cambridge: Cell Press, 2013, roč. 13, č. 6, s. 706-719. ISSN 1934-5909. Dostupné z: https://dx.doi.org/10.1016/j.stem.2013.09.016. |
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@article{1135977,
author = {Matulka, Kamil and Lin, Hsuanandhwai and Hříbková, Hana and Uwanogho, Dafe and Dvořák, Petr and Sun, YuhandMan},
article_location = {Cambridge},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.stem.2013.09.016},
keywords = {Activin/Nodal; protein tyrosine phosphatase 1B ; Activin/ALK4; p-ERK1/2 ;},
language = {eng},
issn = {1934-5909},
journal = {Cell stem cell},
note = {2SGA2878 - projekt SoMoPro Jihomoravského kraje - bohužel nejde dle RIV kombinovat finance územních správních celků a VZ apod.},
title = {PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells},
url = {http://www.sciencedirect.com/science/article/pii/S1934590913004463},
volume = {13},
year = {2013}
}
TY - JOUR
ID - 1135977
AU - Matulka, Kamil - Lin, Hsuan-hwai - Hříbková, Hana - Uwanogho, Dafe - Dvořák, Petr - Sun, Yuh-Man
PY - 2013
TI - PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells
JF - Cell stem cell
VL - 13
IS - 6
SP - 706-719
EP - 706-719
PB - Cell Press
SN - 19345909
N1 - 2SGA2878 - projekt SoMoPro Jihomoravského kraje - bohužel nejde dle RIV kombinovat finance územních správních celků a VZ apod.
KW - Activin/Nodal
KW - protein tyrosine phosphatase 1B
KW - Activin/ALK4
KW - p-ERK1/2 ;
UR - http://www.sciencedirect.com/science/article/pii/S1934590913004463
N2 - During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clear. In this study, we report a role for protein tyrosine phosphatase 1B (PTP1B) in Activin-mediated early fate decisions during ESC differentiation and show that PTP1B acts as an effector of the Activin pathway to specify mesendodermal or neural fate. We found that the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. Subsequently, PTP1B suppresses p-ERK1/2 signaling to inhibit neural specification and promote mesendodermal commitment. These findings suggest that a noncanonical Activin signaling pathway functions in lineage specification of mouse and human embryonic stem cells.
ER -
MATULKA, Kamil, Hsuan-hwai LIN, Hana HŘÍBKOVÁ, Dafe UWANOGHO, Petr DVOŘÁK a Yuh-Man SUN. PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells. \textit{Cell stem cell}. Cambridge: Cell Press, 2013, roč.~13, č.~6, s.~706-719. ISSN~1934-5909. Dostupné z: https://dx.doi.org/10.1016/j.stem.2013.09.016.
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