Can markers of collagen turnover or other biomarkers contribute
to the diagnostics of heart failure with normal left
ventricular ejection fraction?

J 2013

Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?

MELUZÍN, Jaroslav; Josef TOMANDL; Helena PODROUŽKOVÁ; Zdeňka GREGOROVÁ; Vladimír SOŠKA et al.

Základní údaje

Originální název

Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?

Autoři

MELUZÍN, Jaroslav; Josef TOMANDL ; Helena PODROUŽKOVÁ; Zdeňka GREGOROVÁ; Vladimír SOŠKA; Petr DOBŠÁK; Ladislav PECEN a Radka STEPANOVA

Vydání

Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic, Olomouc, Palacký University, 2013, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.661

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00070610

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.5507/bp.2012.110

UT WoS

000329091500011

Klíčová slova anglicky

echocardiography; heart failure with normal ejection fraction; biomarkers

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 3. 2014 22:25, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Aims. Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF). Methods and Results. 91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 ug/L vs. 3.5 ug/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis. Conclusion Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.

Citovat

MELUZÍN, Jaroslav; Josef TOMANDL; Helena PODROUŽKOVÁ; Zdeňka GREGOROVÁ; Vladimír SOŠKA; Petr DOBŠÁK; Ladislav PECEN a Radka STEPANOVA. Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction? Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic. Olomouc: Palacký University, 2013, roč. 157, č. 4, s. 331-339. ISSN 1213-8118. Dostupné z: https://doi.org/10.5507/bp.2012.110.

@article{1137488,
   author = {Meluzín, Jaroslav and Tomandl, Josef and Podroužková, Helena and Gregorová, Zdeňka and Soška, Vladimír and Dobšák, Petr and Pecen, Ladislav and Stepanova, Radka},
   article_location = {Olomouc},
   article_number = {4},
   doi = {https://doi.org/10.5507/bp.2012.110},
   keywords = {echocardiography; heart failure with normal ejection fraction; biomarkers},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic},
   title = {Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?},
   volume = {157},
   year = {2013}
}

TY  - JOUR
ID  - 1137488
AU  - Meluzín, Jaroslav - Tomandl, Josef - Podroužková, Helena - Gregorová, Zdeňka - Soška, Vladimír - Dobšák, Petr - Pecen, Ladislav - Stepanova, Radka
PY  - 2013
TI  - Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?
JF  - Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic
VL  - 157
IS  - 4
SP  - 331-339
EP  - 331-339
PB  - Palacký University
SN  - 12138118
KW  - echocardiography
KW  - heart failure with normal ejection fraction
KW  - biomarkers
N2  - Aims. Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF). Methods and Results. 91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 ug/L vs. 3.5 ug/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis. Conclusion Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.
ER  -

MELUZÍN, Jaroslav; Josef TOMANDL; Helena PODROUŽKOVÁ; Zdeňka GREGOROVÁ; Vladimír SOŠKA; Petr DOBŠÁK; Ladislav PECEN a Radka STEPANOVA. Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction? \textit{Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic}. Olomouc: Palacký University, 2013, roč.~157, č.~4, s.~331-339. ISSN~1213-8118. Dostupné z: https://doi.org/10.5507/bp.2012.110.

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