Psychosis effect on hippocampal reduction in schizophrenia

J 2014

Psychosis effect on hippocampal reduction in schizophrenia

HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ a Tomáš KAŠPÁREK

Základní údaje

Originální název

Psychosis effect on hippocampal reduction in schizophrenia

Název česky

Efekt psychózy na redukci objemu hippokampů u schizofrenie

Autoři

HÝŽA, Martin (203 Česká republika, domácí), Jitka HÜTTLOVÁ (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, garant, domácí)

Vydání

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Oxford, Pergamon-Elsevier Ltd. 2014, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.689

Kód RIV

RIV/00216224:14110/14:00075026

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.pnpbp.2013.10.008

UT WoS

000328074200027

Klíčová slova česky

hipokampus; morfometrie; psychóza; schizofrenie; toxicita

Klíčová slova anglicky

hippocampus; morphometry; psychosis; schizophrenia; toxicity

Štítky

10 02 2014, EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2014 17:03, Soňa Böhmová

Anotace

V originále

Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.

Citovat

HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ a Tomáš KAŠPÁREK. Psychosis effect on hippocampal reduction in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Oxford: Pergamon-Elsevier Ltd., 2014, roč. 48, 3 Jan 2014, s. 186-192. ISSN 0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2013.10.008.

@article{1164082,
   author = {Hýža, Martin and Hüttlová, Jitka and Keřkovský, Miloš and Kašpárek, Tomáš},
   article_location = {Oxford},
   article_number = {3 Jan 2014},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2013.10.008},
   keywords = {hippocampus; morphometry; psychosis; schizophrenia; toxicity},
   language = {eng},
   issn = {0278-5846},
   journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
   title = {Psychosis effect on hippocampal reduction in schizophrenia},
   volume = {48},
   year = {2014}
}

TY  - JOUR
ID  - 1164082
AU  - Hýža, Martin - Hüttlová, Jitka - Keřkovský, Miloš - Kašpárek, Tomáš
PY  - 2014
TI  - Psychosis effect on hippocampal reduction in schizophrenia
JF  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL  - 48
IS  - 3 Jan 2014
SP  - 186-192
EP  - 186-192
PB  - Pergamon-Elsevier Ltd.
SN  - 02785846
KW  - hippocampus
KW  - morphometry
KW  - psychosis
KW  - schizophrenia
KW  - toxicity
N2  - Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.
ER  -

HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ a Tomáš KAŠPÁREK. Psychosis effect on hippocampal reduction in schizophrenia. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Oxford: Pergamon-Elsevier Ltd., 2014, roč.~48, 3 Jan 2014, s.~186-192. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2013.10.008.

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