NOS3 894G > T Polymorphism is Associated With Progression of
Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic
Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

J 2014

NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

KURICOVÁ, Katarína; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Vendula BARTÁKOVÁ; Lucie BROŽOVÁ et al.

Základní údaje

Originální název

NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

Autoři

KURICOVÁ, Katarína; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Vendula BARTÁKOVÁ ; Lucie BROŽOVÁ; Jiří JARKOVSKÝ a Kateřina KAŇKOVÁ

Vydání

Kidney and Blood Pressure Research, Karger, 2014, 1420-4096

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.123

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00080127

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diabetic nephropathy; Nitric oxide synthase; Polymorphism; Cardiovascular morbidity

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 4. 2015 14:29, Soňa Böhmová

Anotace

V originále

Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GTgenotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 – 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 – 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.

Návaznosti

NT11405, projekt VaV

Název: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministerstvo zdravotnictví ČR, Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Citovat

KURICOVÁ, Katarína; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Vendula BARTÁKOVÁ; Lucie BROŽOVÁ; Jiří JARKOVSKÝ a Kateřina KAŇKOVÁ. NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? Kidney and Blood Pressure Research. Karger, 2014, roč. 38, č. 1, s. 92-98. ISSN 1420-4096. Dostupné z: https://doi.org/10.1159/000355757.

@article{1173911,
   author = {Kuricová, Katarína and Dvořáková, Veronika and Pácal, Lukáš and Bartáková, Vendula and Brožová, Lucie and Jarkovský, Jiří and Kaňková, Kateřina},
   article_number = {1},
   doi = {https://doi.org/10.1159/000355757},
   keywords = {Diabetic nephropathy; Nitric oxide synthase; Polymorphism; Cardiovascular morbidity},
   language = {eng},
   issn = {1420-4096},
   journal = {Kidney and Blood Pressure Research},
   title = {NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?},
   url = {http://www.karger.com/Article/Pdf/355757},
   volume = {38},
   year = {2014}
}

TY  - JOUR
ID  - 1173911
AU  - Kuricová, Katarína - Dvořáková, Veronika - Pácal, Lukáš - Bartáková, Vendula - Brožová, Lucie - Jarkovský, Jiří - Kaňková, Kateřina
PY  - 2014
TI  - NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?
JF  - Kidney and Blood Pressure Research
VL  - 38
IS  - 1
SP  - 92-98
EP  - 92-98
PB  - Karger
SN  - 14204096
KW  - Diabetic nephropathy
KW  - Nitric oxide synthase
KW  - Polymorphism
KW  - Cardiovascular morbidity
UR  - http://www.karger.com/Article/Pdf/355757
N2  - Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GTgenotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 – 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 – 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.
ER  -

KURICOVÁ, Katarína; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Vendula BARTÁKOVÁ; Lucie BROŽOVÁ; Jiří JARKOVSKÝ a Kateřina KAŇKOVÁ. NOS3 894G \&{}gt; T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? \textit{Kidney and Blood Pressure Research}. Karger, 2014, roč.~38, č.~1, s.~92-98. ISSN~1420-4096. Dostupné z: https://doi.org/10.1159/000355757.

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