2014
Cysteine peptidase inhibitors of helminths
ILGOVÁ, Jana; Milan GELNAR; Břetislav KOUDELA a Martin KAŠNÝZákladní údaje
Originální název
Cysteine peptidase inhibitors of helminths
Autoři
Vydání
XXI. Helminthological Days, 2014
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
10600 1.6 Biological sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/14:00073621
Organizační jednotka
Přírodovědecká fakulta
ISBN
978-80-210-6796-7
Klíčová slova anglicky
cysteine peptidase inhibitors; helminths; immunomodulation
Změněno: 12. 5. 2014 14:26, Mgr. et Mgr. Jana Ilgová, Ph.D.
Anotace
V originále
Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomic groups – Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected genes. The recombinant forms of particular CPI will be prepared and characterized in detail to reveal their function.
Návaznosti
| GAP506/12/1258, projekt VaV |
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| GBP505/12/G112, projekt VaV |
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