Abnormalities in Myelination of the Superior Cerebellar
Peduncle in Patients with Schizophrenia and Deficits in
Movement Sequencing

J 2014

Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing

HÜTTLOVÁ, Jitka; Zora KIKINIS; Miloš KEŘKOVSKÝ; Sylvain BOUIX; Vu MAI-ANH et al.

Základní údaje

Originální název

Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing

Autoři

HÜTTLOVÁ, Jitka; Zora KIKINIS; Miloš KEŘKOVSKÝ; Sylvain BOUIX; Vu MAI-ANH; Nikos MAKRIS; Martha SHENTON a Tomáš KAŠPÁREK

Vydání

Cerebellum, New York, Springer, 2014, 1473-4222

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.717

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00080135

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cerebellum; Cerebral peduncle; Corticospinal tracts; Diffusion tensor imaging; Psychomotor disorders; Schizophrenia

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 9. 2014 14:39, Soňa Böhmová

Anotace

V originále

Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n = 7), and those with normal performance, the SQnorm group (n = 17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.

Návaznosti

CZ.1.05/1.1.00/02.0068, interní kód MU

Název: CEITEC - středoevropský technologický institut (Akronym: CEITEC)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC - středoevropský technologický institut, 1.1 Evropská centra excelence

NT13437, projekt VaV

Název: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

HÜTTLOVÁ, Jitka; Zora KIKINIS; Miloš KEŘKOVSKÝ; Sylvain BOUIX; Vu MAI-ANH; Nikos MAKRIS; Martha SHENTON a Tomáš KAŠPÁREK. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. Cerebellum. New York: Springer, 2014, roč. 13, č. 4, s. 415-424. ISSN 1473-4222. Dostupné z: https://doi.org/10.1007/s12311-014-0550-y.

@article{1186382,
   author = {Hüttlová, Jitka and Kikinis, Zora and Keřkovský, Miloš and Bouix, Sylvain and MaiandAnh, Vu and Makris, Nikos and Shenton, Martha and Kašpárek, Tomáš},
   article_location = {New York},
   article_number = {4},
   doi = {https://doi.org/10.1007/s12311-014-0550-y},
   keywords = {Cerebellum; Cerebral peduncle; Corticospinal tracts; Diffusion tensor imaging; Psychomotor disorders; Schizophrenia},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing},
   volume = {13},
   year = {2014}
}

TY  - JOUR
ID  - 1186382
AU  - Hüttlová, Jitka - Kikinis, Zora - Keřkovský, Miloš - Bouix, Sylvain - Mai-Anh, Vu - Makris, Nikos - Shenton, Martha - Kašpárek, Tomáš
PY  - 2014
TI  - Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing
JF  - Cerebellum
VL  - 13
IS  - 4
SP  - 415-424
EP  - 415-424
PB  - Springer
SN  - 14734222
KW  - Cerebellum
KW  - Cerebral peduncle
KW  - Corticospinal tracts
KW  - Diffusion tensor imaging
KW  - Psychomotor disorders
KW  - Schizophrenia
N2  - Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n = 7), and those with normal performance, the SQnorm group (n = 17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.
ER  -

HÜTTLOVÁ, Jitka; Zora KIKINIS; Miloš KEŘKOVSKÝ; Sylvain BOUIX; Vu MAI-ANH; Nikos MAKRIS; Martha SHENTON a Tomáš KAŠPÁREK. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. \textit{Cerebellum}. New York: Springer, 2014, roč.~13, č.~4, s.~415-424. ISSN~1473-4222. Dostupné z: https://doi.org/10.1007/s12311-014-0550-y.

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