TaqI polymorphism in the vitamin D receptor (VDR) and its
relation to aggressive and chronic periodontitis in Czech
population

k 2014

TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population

MAGURA, Matej; Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Základní údaje

Originální název

TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population

Autoři

MAGURA, Matej; Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

IADS & YDW MidYear Meeting 2014, Tunisia, 2014

Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Klíčová slova anglicky

periodontitis, TaqI, VDR, Czech population

Změněno: 30. 6. 2014 07:36, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA

Anotace

V originále

Objective: Periodontitis is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to analyze a single nucleotide polymorphism (SNP) in the VDR gene, which may affect the functional activity of the VDR protein, in Czech patients with aggressive (AgP) and chronic periodontitis (CP). Methods: In this case-control study 448 unrelated subjects were included. Genomic DNA of 67 patients with AgP, 305 patients with CP and 76 healthy/non-periodontitis controls were genotyped. For TaqI VDR (rs731236) gene polymorphism the method based on polymerase chain reaction (PCR) followed by restriction digest was used. Results: There was no evidence for a significant association between TaqI VDR polymorphism and CP, while allele frequencies of TaqI VDR polymorphism was significantly different between patients with AgP and non-periodontitis controls (P = 0.015). And although no difference was found in genotype frequencies in patients with AgP, statistically significant results were obtained after comparing the genotypes TT vs CT + CC (P = 0.034), in the subgroup of women (N = 40, P = 0.017). Conclusions: We can conclude relationship between the occurrence of the mutated allele (C) of TaqI VDR polymorphism and the development of aggressive forms of periodontitis, especially in women, but a correlation between mutation and chronic form of periodontitis was not found.

Návaznosti

NT11405, projekt VaV

Název: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministerstvo zdravotnictví ČR, Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Citovat

MAGURA, Matej; Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population. In IADS & YDW MidYear Meeting 2014, Tunisia. 2014.

@proceedings{1187916,
   author = {Magura, Matej and Bořilová Linhartová, Petra and Izakovičová Hollá, Lydie},
   booktitle = {IADS & YDW MidYear Meeting 2014, Tunisia},
   keywords = {periodontitis, TaqI, VDR, Czech population},
   title = {TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population},
   year = {2014}
}

TY  - CONF
ID  - 1187916
AU  - Magura, Matej - Bořilová Linhartová, Petra - Izakovičová Hollá, Lydie
PY  - 2014
TI  - TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population
KW  - periodontitis, TaqI, VDR, Czech population
N2  - Objective: Periodontitis is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to analyze a single nucleotide polymorphism (SNP) in the VDR gene, which may affect the functional activity of the VDR protein, in Czech patients with aggressive (AgP) and chronic periodontitis (CP). Methods: In this case-control study 448 unrelated subjects were included. Genomic DNA of 67 patients with AgP, 305 patients with CP and 76 healthy/non-periodontitis controls were genotyped. For TaqI VDR (rs731236) gene polymorphism the method based on polymerase chain reaction (PCR) followed by restriction digest was used. Results: There was no evidence for a significant association between TaqI VDR polymorphism and CP, while allele frequencies of TaqI VDR polymorphism was significantly different between patients with AgP and non-periodontitis controls (P = 0.015). And although no difference was found in genotype frequencies in patients with AgP, statistically significant results were obtained after comparing the genotypes TT vs CT + CC (P = 0.034), in the subgroup of women (N = 40, P = 0.017). Conclusions: We can conclude relationship between the occurrence of the mutated allele (C) of TaqI VDR polymorphism and the development of aggressive forms of periodontitis, especially in women, but a correlation between mutation and chronic form of periodontitis was not found.
ER  -

Přehled o publikaci