ELIÁŠOVÁ, Ilona, Ľubomíra ANDERKOVÁ, Radek MAREČEK a Irena REKTOROVÁ. Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study. Journal of the neurological sciences, Netherlands: Amsterdam : Elsevier, 2014, roč. 346, 1-2, s. 318-322. ISSN 0022-510X. doi:10.1016/j.jns.2014.08.036.
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Základní údaje
Originální název Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study
Autoři ELIÁŠOVÁ, Ilona (203 Česká republika, domácí), Ľubomíra ANDERKOVÁ (703 Slovensko, domácí), Radek MAREČEK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí).
Vydání Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2014, 0022-510X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 3. Medical and Health Sciences
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.474
Kód RIV RIV/00216224:14740/14:00076257
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1016/j.jns.2014.08.036
UT WoS 000345947400055
Klíčová slova anglicky rTMS; noninvasive brain stimulation; inferior frontal gyrus; MCI; Alzheimer’s disease; attention; cognitive speed; executive function
Štítky kontrola MP, rivok, SCOPUS
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. et Mgr. Ľubomíra Anderková, Ph.D., učo 262093. Změněno: 13. 3. 2018 13:27.
Anotace
Introduction Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive tool for modulating cortical activity. Objectives In this pilot study, we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) or incipient dementia due to Alzheimer’s disease (AD). Methods Ten patients (6 men; 4 women, mean age 72 ± 8 years; MMSE 23 ± 3.56) were enrolled in a randomized, placebo-controlled study with a crossover design. All participants received 2 sessions of 10 Hz rTMS over the non-dominant right hemisphere in random order: IFG (active stimulation site) and vertex (control stimulation site). Intensities were adjusted to 90% of resting motor threshold. A total of 2250 pulses were applied in a session. The Trail Making Test (TMT), the Stroop test, and the complex visual scene encoding task (CVSET) were administered before and immediately after each session. The Wilcoxon paired test was used for data analysis. Results Stimulation applied over the IFG induced improvement in the TMT parts A (p = 0.037) and B (p = 0.049). No significant changes were found in the Stroop test or the CVSET after the IFG stimulation. We observed no significant cognitive aftereffects of rTMS applied over the vertex. Conclusions High frequency rTMS of the right IFG induced significant improvement of attention and psychomotor speed in patients with MCI/mild dementia due to AD. This pilot study is part of a more complex protocol and ongoing research.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
VytisknoutZobrazeno: 19. 10. 2019 07:28