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@article{1197182,
author = {Lipková, Jolana and Pařenica, Jiří and Ďuriš, Kamil and Helanova, Katerina and Tomandl, Josef and Kubková, Lenka and Vašků, Anna and Pávková Goldbergová, Monika},
article_location = {Milan},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s10238-014-0294-5},
keywords = {chemokines; RANTES; acute myocardial infarction; cardiogenic shock},
language = {eng},
issn = {1591-8890},
journal = {Clinical and Experimental Medicine},
title = {Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock},
volume = {15},
year = {2015}
}
TY - JOUR
ID - 1197182
AU - Lipková, Jolana - Pařenica, Jiří - Ďuriš, Kamil - Helanova, Katerina - Tomandl, Josef - Kubková, Lenka - Vašků, Anna - Pávková Goldbergová, Monika
PY - 2015
TI - Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock
JF - Clinical and Experimental Medicine
VL - 15
IS - 3
SP - 405-414
EP - 405-414
PB - SPRINGER-VERLAG ITALIA SRL
SN - 15918890
KW - chemokines
KW - RANTES
KW - acute myocardial infarction
KW - cardiogenic shock
N2 - Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A total of 609 patients with ST-segment elevation myocardial infarction, 43 patients with cardiogenic shock and 130 control subjects were enrolled in the study. RANTES -403G/A promoter polymorphism and baseline serum RANTES levels were analyzed. In the present study, we associated RANTES -403G/A promoter polymorphism with acute heart failure in patients with myocardial infarction (p = 0.006) and ejection fraction 3 months after MI onset (p = 0.02). Further, a difference in circulating RANTES levels among controls and STEMI subjects, and a relation of serum levels with acute heart failure was observed (p = 0.03, p = 0.003, respectively). We found a significant difference when comparing cardiogenic shock patients and controls (p < 0.001), with the most significant difference between cardiogenic shock and AHF subgroup of STEMI patients (p < 0.001). We observed a decreasing tendency of serum RANTES levels with the severity of myocardial infarction and progression, with the lowest levels in patients with cardiogenic shock (cutoff level a parts per thousand yen80.4 ng/ml). Our results suggest the role of RANTES as a potential biomarker of cardiogenic shock and acute heart failure in the hospital phase after myocardial infarction.
ER -
LIPKOVÁ, Jolana, Jiří PAŘENICA, Kamil ĎURIŠ, Katerina HELANOVA, Josef TOMANDL, Lenka KUBKOVÁ, Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock. Online. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2015, roč.~15, č.~3, s.~405-414. ISSN~1591-8890. Dostupné z: https://dx.doi.org/10.1007/s10238-014-0294-5. [citováno 2024-04-24]
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