Association of circulating levels of RANTES and -403G/A
promoter polymorphism to acute heart failure after STEMI and to
cardiogenic shock

J 2015

Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock

LIPKOVÁ, Jolana; Jiří PAŘENICA; Kamil ĎURIŠ; Katerina HELANOVA; Josef TOMANDL et al.

Základní údaje

Originální název

Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock

Název česky

Asociace hladiny RANTES z cirkulace a -403G/A promotorového polymorfismu s akutním srdečním selháním po STEMI a kardiogenním šokem

Autoři

LIPKOVÁ, Jolana ; Jiří PAŘENICA; Kamil ĎURIŠ; Katerina HELANOVA; Josef TOMANDL ; Lenka KUBKOVÁ; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ

Vydání

Clinical and Experimental Medicine, Milan, SPRINGER-VERLAG ITALIA SRL, 2015, 1591-8890

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.854

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082101

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

chemokiny; RANTES; akutní infarkt myokardu; kardiogenní šok

Klíčová slova anglicky

chemokines; RANTES; acute myocardial infarction; cardiogenic shock

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 9. 2015 12:06, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A total of 609 patients with ST-segment elevation myocardial infarction, 43 patients with cardiogenic shock and 130 control subjects were enrolled in the study. RANTES -403G/A promoter polymorphism and baseline serum RANTES levels were analyzed. In the present study, we associated RANTES -403G/A promoter polymorphism with acute heart failure in patients with myocardial infarction (p = 0.006) and ejection fraction 3 months after MI onset (p = 0.02). Further, a difference in circulating RANTES levels among controls and STEMI subjects, and a relation of serum levels with acute heart failure was observed (p = 0.03, p = 0.003, respectively). We found a significant difference when comparing cardiogenic shock patients and controls (p < 0.001), with the most significant difference between cardiogenic shock and AHF subgroup of STEMI patients (p < 0.001). We observed a decreasing tendency of serum RANTES levels with the severity of myocardial infarction and progression, with the lowest levels in patients with cardiogenic shock (cutoff level a parts per thousand yen80.4 ng/ml). Our results suggest the role of RANTES as a potential biomarker of cardiogenic shock and acute heart failure in the hospital phase after myocardial infarction.

Návaznosti

MUNI/A/1003/2013, interní kód MU

Název: Molekulární patofyziologie vybraných komplexních nemocí

Investor: Masarykova univerzita, Molekulární patofyziologie vybraných komplexních nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

LIPKOVÁ, Jolana; Jiří PAŘENICA; Kamil ĎURIŠ; Katerina HELANOVA; Josef TOMANDL; Lenka KUBKOVÁ; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock. Clinical and Experimental Medicine. Milan: SPRINGER-VERLAG ITALIA SRL, 2015, roč. 15, č. 3, s. 405-414. ISSN 1591-8890. Dostupné z: https://doi.org/10.1007/s10238-014-0294-5.

@article{1197182,
   author = {Lipková, Jolana and Pařenica, Jiří and Ďuriš, Kamil and Helanova, Katerina and Tomandl, Josef and Kubková, Lenka and Vašků, Anna and Pávková Goldbergová, Monika},
   article_location = {Milan},
   article_number = {3},
   doi = {https://doi.org/10.1007/s10238-014-0294-5},
   keywords = {chemokines; RANTES; acute myocardial infarction; cardiogenic shock},
   language = {eng},
   issn = {1591-8890},
   journal = {Clinical and Experimental Medicine},
   title = {Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock},
   volume = {15},
   year = {2015}
}

TY  - JOUR
ID  - 1197182
AU  - Lipková, Jolana - Pařenica, Jiří - Ďuriš, Kamil - Helanova, Katerina - Tomandl, Josef - Kubková, Lenka - Vašků, Anna - Pávková Goldbergová, Monika
PY  - 2015
TI  - Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock
JF  - Clinical and Experimental Medicine
VL  - 15
IS  - 3
SP  - 405-414
EP  - 405-414
PB  - SPRINGER-VERLAG ITALIA SRL
SN  - 15918890
KW  - chemokines
KW  - RANTES
KW  - acute myocardial infarction
KW  - cardiogenic shock
N2  - Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A total of 609 patients with ST-segment elevation myocardial infarction, 43 patients with cardiogenic shock and 130 control subjects were enrolled in the study. RANTES -403G/A promoter polymorphism and baseline serum RANTES levels were analyzed. In the present study, we associated RANTES -403G/A promoter polymorphism with acute heart failure in patients with myocardial infarction (p = 0.006) and ejection fraction 3 months after MI onset (p = 0.02). Further, a difference in circulating RANTES levels among controls and STEMI subjects, and a relation of serum levels with acute heart failure was observed (p = 0.03, p = 0.003, respectively). We found a significant difference when comparing cardiogenic shock patients and controls (p < 0.001), with the most significant difference between cardiogenic shock and AHF subgroup of STEMI patients (p < 0.001). We observed a decreasing tendency of serum RANTES levels with the severity of myocardial infarction and progression, with the lowest levels in patients with cardiogenic shock (cutoff level a parts per thousand yen80.4 ng/ml). Our results suggest the role of RANTES as a potential biomarker of cardiogenic shock and acute heart failure in the hospital phase after myocardial infarction.
ER  -

LIPKOVÁ, Jolana; Jiří PAŘENICA; Kamil ĎURIŠ; Katerina HELANOVA; Josef TOMANDL; Lenka KUBKOVÁ; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2015, roč.~15, č.~3, s.~405-414. ISSN~1591-8890. Dostupné z: https://doi.org/10.1007/s10238-014-0294-5.

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