| MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. Experimental and Clinical Cardiology. Oakville: Pulsus Group, 2014, roč. 20, č. 8, s. 3204-3217. ISSN 1205-6626. |
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@article{1199947,
author = {Meluzín, Jaroslav and Kára, Tomáš and Belehrad, Milos and Stárek, Zdeněk and Stepanova, Radka and Mikušová, Tereza and Podroužková, Helena and Špinarová, Monika and Soucek, Miroslav and Soška, Vladimír},
article_location = {Oakville},
article_number = {8},
keywords = {Diastolic dysfunction; Heart failure; Sleep apnea},
language = {eng},
issn = {1205-6626},
journal = {Experimental and Clinical Cardiology},
title = {Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension},
volume = {20},
year = {2014}
}
TY - JOUR
ID - 1199947
AU - Meluzín, Jaroslav - Kára, Tomáš - Belehrad, Milos - Stárek, Zdeněk - Stepanova, Radka - Mikušová, Tereza - Podroužková, Helena - Špinarová, Monika - Soucek, Miroslav - Soška, Vladimír
PY - 2014
TI - Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
JF - Experimental and Clinical Cardiology
VL - 20
IS - 8
SP - 3204-3217
EP - 3204-3217
PB - Pulsus Group
SN - 12056626
KW - Diastolic dysfunction
KW - Heart failure
KW - Sleep apnea
N2 - Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia.
ER -
MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. \textit{Experimental and Clinical Cardiology}. Oakville: Pulsus Group, 2014, roč.~20, č.~8, s.~3204-3217. ISSN~1205-6626.
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