Significant association of diastolic dysfunction and heart
failure with severe sleep apnea-induced hypoxemia in patients
with drug-resistant hypertension

J 2014

Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension

MELUZÍN, Jaroslav; Tomáš KÁRA; Milos BELEHRAD; Zdeněk STÁREK; Radka STEPANOVA et al.

Základní údaje

Originální název

Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension

Autoři

MELUZÍN, Jaroslav; Tomáš KÁRA; Milos BELEHRAD; Zdeněk STÁREK; Radka STEPANOVA; Tereza MIKUŠOVÁ; Helena PODROUŽKOVÁ; Monika ŠPINAROVÁ; Miroslav SOUCEK a Vladimír SOŠKA

Vydání

Experimental and Clinical Cardiology, Oakville, Pulsus Group, 2014, 1205-6626

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.758 v roce 2013

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00076660

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diastolic dysfunction; Heart failure; Sleep apnea

Štítky

EL OK

Příznaky

Recenzováno

Změněno: 30. 9. 2014 16:36, Soňa Böhmová

Anotace

V originále

Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia.

Citovat

MELUZÍN, Jaroslav; Tomáš KÁRA; Milos BELEHRAD; Zdeněk STÁREK; Radka STEPANOVA; Tereza MIKUŠOVÁ; Helena PODROUŽKOVÁ; Monika ŠPINAROVÁ; Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. Experimental and Clinical Cardiology. Oakville: Pulsus Group, 2014, roč. 20, č. 8, s. 3204-3217. ISSN 1205-6626.

@article{1199947,
   author = {Meluzín, Jaroslav and Kára, Tomáš and Belehrad, Milos and Stárek, Zdeněk and Stepanova, Radka and Mikušová, Tereza and Podroužková, Helena and Špinarová, Monika and Soucek, Miroslav and Soška, Vladimír},
   article_location = {Oakville},
   article_number = {8},
   keywords = {Diastolic dysfunction; Heart failure; Sleep apnea},
   language = {eng},
   issn = {1205-6626},
   journal = {Experimental and Clinical Cardiology},
   title = {Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension},
   volume = {20},
   year = {2014}
}

TY  - JOUR
ID  - 1199947
AU  - Meluzín, Jaroslav - Kára, Tomáš - Belehrad, Milos - Stárek, Zdeněk - Stepanova, Radka - Mikušová, Tereza - Podroužková, Helena - Špinarová, Monika - Soucek, Miroslav - Soška, Vladimír
PY  - 2014
TI  - Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
JF  - Experimental and Clinical Cardiology
VL  - 20
IS  - 8
SP  - 3204-3217
EP  - 3204-3217
PB  - Pulsus Group
SN  - 12056626
KW  - Diastolic dysfunction
KW  - Heart failure
KW  - Sleep apnea
N2  - Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia.
ER  -

MELUZÍN, Jaroslav; Tomáš KÁRA; Milos BELEHRAD; Zdeněk STÁREK; Radka STEPANOVA; Tereza MIKUŠOVÁ; Helena PODROUŽKOVÁ; Monika ŠPINAROVÁ; Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. \textit{Experimental and Clinical Cardiology}. Oakville: Pulsus Group, 2014, roč.~20, č.~8, s.~3204-3217. ISSN~1205-6626.

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