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@article{1202693,
author = {Dolejská, Monika and Brhelová, Eva and Dobiášová, Hana and Krivdova, Jana and Juránková, Jana and Ševčíková, Alena and Dubská, Lenka and Literák, Ivan and Čížek, Alois and Vavřina, Martin and Kutnikova, Lucia and Štěrba, Jaroslav},
article_location = {AMSTERDAM, NETHERLANDS},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.ijantimicag.2012.07.016},
issn = {0924-8579},
journal = {International Journal of Antimicrobial Agent},
title = {Dissemination of IncFII(K)-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from children in hospital paediatric oncology wards},
volume = {40},
year = {2012}
}
TY - JOUR
ID - 1202693
AU - Dolejská, Monika - Brhelová, Eva - Dobiášová, Hana - Krivdova, Jana - Juránková, Jana - Ševčíková, Alena - Dubská, Lenka - Literák, Ivan - Čížek, Alois - Vavřina, Martin - Kutnikova, Lucia - Štěrba, Jaroslav
PY - 2012
TI - Dissemination of IncFII(K)-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from children in hospital paediatric oncology wards
JF - International Journal of Antimicrobial Agent
VL - 40
IS - 6
SP - 510-515
EP - 510-515
PB - ELSEVIER SCIENCE
SN - 09248579
N2 - In this study, extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae isolates in children with malignancies hospitalised at a paediatric oncology department in the Czech Republic were investigated. From June 2009 to January 2010, a total of 50 ESBL-producing faecal isolates of Enterobacteriaceae were obtained from 28 patients. These isolates were characterised with regard to ESBL enzymes, plasmid-mediated quinolone resistance genes, multilocus sequence typing (MLST) and plasmids conferring resistance to cephalosporins and fluoroquinolones. ESBL-producing isolates included Klebsiella pneumoniae (n = 36), Escherichia coli (n = 7), Klebsiella oxytoca (n = 3), Enterobacter cloacae (n = 2) and Citrobacter freundii (n = 2). Klebsiella pneumoniae isolates belonged to 7 MLST types, including sequence types ST280, ST321, ST323 and ST416 as well as the novel types ST626, ST627 and ST628. The multiresistant epidemic clone E. coli B2-O25b-ST131 was detected in one patient. The gene bla(CTX-M-15) was found on large conjugative IncFII(K) plasmids along with bla(TEM-1), bla(OXA-1), qnrB1, aac(6')-Ib-cr, strA, sul2, aac(3')-II and tet(A) genes in most isolates. Dissemination of IncFII(K) plasmids among various Enterobacteriaceae isolates was considered an important aspect of nosocomial colonisation in the wards by Enterobacteriaceae species producing ESBLs. This is the first study documenting multiple antibiotic resistance elements, including qnr genes, in IncFII(K) plasmids in various bacterial species isolated in a single hospital department. The results highlight the evolution of IncFII(K) plasmids into new variants containing novel antibiotic resistance elements and their important role in spreading ESBL-producing bacteria among hospitalised patients. (c) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
ER -
DOLEJSKÁ, Monika, Eva BRHELOVÁ, Hana DOBIÁŠOVÁ, Jana KRIVDOVA, Jana JURÁNKOVÁ, Alena ŠEVČÍKOVÁ, Lenka DUBSKÁ, Ivan LITERÁK, Alois ČÍŽEK, Martin VAVŘINA, Lucia KUTNIKOVA a Jaroslav ŠTĚRBA. Dissemination of IncFII(K)-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from children in hospital paediatric oncology wards. \textit{International Journal of Antimicrobial Agent}. AMSTERDAM, NETHERLANDS: ELSEVIER SCIENCE, 2012, roč.~40, č.~6, s.~510-515. ISSN~0924-8579. Dostupné z: https://dx.doi.org/10.1016/j.ijantimicag.2012.07.016.
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