| ROUBALOVÁ, Eva, Veronika KVARDOVÁ, Roman HRSTKA, Šárka BOŘILOVÁ, Eva MICHALOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Petra SCHARTLMUELLER, Petr SOVA a Bořivoj VOJTĚŠEK. The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12. Investigational New Drugs. DORDRECHT: SPRINGER, 2010, roč. 28, č. 4, s. 445-453. ISSN 0167-6997. Dostupné z: https://dx.doi.org/10.1007/s10637-009-9270-4. |
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@article{1202741,
author = {Roubalová, Eva and Kvardová, Veronika and Hrstka, Roman and Bořilová, Šárka and Michalová, Eva and Zdražilová Dubská, Lenka and Schartlmueller, Petra and Sova, Petr and Vojtěšek, Bořivoj},
article_location = {DORDRECHT},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s10637-009-9270-4},
issn = {0167-6997},
journal = {Investigational New Drugs},
title = {The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12},
volume = {28},
year = {2010}
}
TY - JOUR
ID - 1202741
AU - Roubalová, Eva - Kvardová, Veronika - Hrstka, Roman - Bořilová, Šárka - Michalová, Eva - Zdražilová Dubská, Lenka - Schartlmueller, Petra - Sova, Petr - Vojtěšek, Bořivoj
PY - 2010
TI - The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12
JF - Investigational New Drugs
VL - 28
IS - 4
SP - 445-453
EP - 445-453
PB - SPRINGER
SN - 01676997
N2 - In this study, we characterized the effects of LA-12 on tumor cell lines possessing wild type p53 and on p53-deficient/mutant cell lines and the results were compared to those obtained using cisplatin. We have determined changes of p53 levels, of its transcriptional activity, of its posttranscriptional modifications and the effect of the treatment on the cell cycle, on the induction of apoptosis and on gene expression. LA-12 induces weak accumulation of both transcriptionally active p53 tumor suppressor and of p21(WAF1/CIP1) protein. LA-12 and cisplatin also significantly differ in their effects on apoptosis and cell cycle and on gene expression spectra in studied cell lines. LA-12 induces higher apoptosis levels in comparison with those induced by cisplatin, especially in p53-deficient H1299 cells and in MCF-7DD cells with transcriptionally inactive p53. We suggest that LA-12-mediated apoptosis is not fully dependent on p53. This confirms the therapeutic potential of LA-12 as a more potent cytostatic agent for both tumor cells expressing wild type p53 and for p53-deficient or mutant cells.
ER -
ROUBALOVÁ, Eva, Veronika KVARDOVÁ, Roman HRSTKA, Šárka BOŘILOVÁ, Eva MICHALOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Petra SCHARTLMUELLER, Petr SOVA a Bořivoj VOJTĚŠEK. The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12. \textit{Investigational New Drugs}. DORDRECHT: SPRINGER, 2010, roč.~28, č.~4, s.~445-453. ISSN~0167-6997. Dostupné z: https://dx.doi.org/10.1007/s10637-009-9270-4.
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