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@proceedings{1202786,
author = {Pekarčíková, Lucie and Knopfová, Lucia and Šmarda, Jan},
booktitle = {Translational advances in cancer cell signalling and metabolism},
keywords = {c-Myb, colorectal carcinoma cells, cytotoxic agents, signalling pathways},
language = {eng},
title = {The role of c-Myb in oxidative stress: new strategies of anticancer therapy of colorectal carcinomas?},
year = {2014}
}
TY - CONF
ID - 1202786
AU - Pekarčíková, Lucie - Knopfová, Lucia - Šmarda, Jan
PY - 2014
TI - The role of c-Myb in oxidative stress: new strategies of anticancer therapy of colorectal carcinomas?
KW - c-Myb, colorectal carcinoma cells, cytotoxic agents, signalling pathways
N2 - Colorectal carcinoma is the third most common cancer in the world. c-Myb is transcription factor and its overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival of patients. The aim of this study is to decipher signaling events underpinning the c-Myb-induced chemoresistance of CRC cells. We showed that c-Myb is significantly involved in pro-survival signaling pathways. We described a novel c-Myb-p38δ/JNK signal axis mediating increased resistance of CRC cells to cytotoxic agents and documented for the first time that the prosurvival role of c-Myb is associated with deregulation of reactive oxygen species (ROS). Moreover, we found positive correlation between levels of c-Myb, ROS and pAMPK kinase in CRC cells and we open new question on the role of c-Myb in metabolic precesses of CRC cells.
ER -
PEKARČÍKOVÁ, Lucie, Lucia KNOPFOVÁ a Jan ŠMARDA. The role of c-Myb in oxidative stress: new strategies of anticancer therapy of colorectal carcinomas? In \textit{Translational advances in cancer cell signalling and metabolism}. 2014.
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