Vasospasm of the Flap Pedicle: The Effect of 11 of the Most
Often Used Vasodilating Drugs. Comparative Study in a Rat Model

J 2014

Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model

HÝŽA, Petr; Libor STREIT; Daniel SCHWARZ; Tomáš KUBEK; Jiří VESELÝ et al.

Základní údaje

Originální název

Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model

Autoři

HÝŽA, Petr; Libor STREIT; Daniel SCHWARZ; Tomáš KUBEK a Jiří VESELÝ

Vydání

PLASTIC AND RECONSTRUCTIVE SURGERY, Philadelphia, Lippincott Williams & Wilkins, 2014, 0032-1052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.993

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00080165

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

MICROCIRCULATORY INTRAVASCULAR THROMBOSIS; ANEURYSMAL SUBARACHNOID HEMORRHAGE; MAGNESIUM-SULFATE; SKIN FLAPS; MICROVASCULAR SURGERY; CONSCIOUS RATS; METHYL-ESTER; TOPICAL USE; IN-VITRO; ISCHEMIA

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2015 15:29, Soňa Böhmová

Anotace

V originále

Background: There has been no review study published yet comparing the effects of the vasodilating drugs that are most often used in clinical practice empirically. The aim of the authors' study was to perform this comparison and to select the drugs that are able to release vasospasm and the drugs that reduce vasospasm duration most effectively in an experimental model in vivo. Methods: Pedicled groin flaps were dissected in 300 male Wistar rats. Vasospasm was induced by tension applied on the pedicle in the axial direction using a 15-g weight. The blood perfusion of the flap was monitored using a laser Doppler device. The duration of vasospasm was defined as the time from the release of tension until blood flow began to rise. These times were detected using automated computerized detection. The effects of 11 different drugs were studied in 14 groups. The drugs were applied locally; some of them were tested in different concentrations or applied parenterally. Results: Ten percent magnesium sulfate reduced the duration of vasospasm most effectively (p < 0.01). Verapamil applied locally and also pentoxifylline applied parenterally were also very effective. In contrast, the duration of vasospasm was extended after local application of 2% lidocaine (p < 0.01). Conclusions: The authors concluded that 10% magnesium sulfate applied locally has the best ability to relieve surgically induced vasospasm because of the highest level of significance and reliability. The finding that local application of 2% lidocaine prolongs vasospasm may be surprising.

Návaznosti

NR8368, projekt VaV

Název: Spazmy cév mikrochirurgicky přenášených laloků a možnosti jejich ovlivnění

Investor: Ministerstvo zdravotnictví ČR, Spazmy cév mikrochirurgicky přenášených laloků a možnosti jejich ovlivnění

Citovat

HÝŽA, Petr; Libor STREIT; Daniel SCHWARZ; Tomáš KUBEK a Jiří VESELÝ. Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model. PLASTIC AND RECONSTRUCTIVE SURGERY. Philadelphia: Lippincott Williams & Wilkins, 2014, roč. 134, č. 4, s. "574E"-"584E", 11 s. ISSN 0032-1052. Dostupné z: https://doi.org/10.1097/PRS.0000000000000570.

@article{1217456,
   author = {Hýža, Petr and Streit, Libor and Schwarz, Daniel and Kubek, Tomáš and Veselý, Jiří},
   article_location = {Philadelphia},
   article_number = {4},
   doi = {https://doi.org/10.1097/PRS.0000000000000570},
   keywords = {MICROCIRCULATORY INTRAVASCULAR THROMBOSIS; ANEURYSMAL SUBARACHNOID HEMORRHAGE; MAGNESIUM-SULFATE; SKIN FLAPS; MICROVASCULAR SURGERY; CONSCIOUS RATS; METHYL-ESTER; TOPICAL USE; IN-VITRO; ISCHEMIA},
   language = {eng},
   issn = {0032-1052},
   journal = {PLASTIC AND RECONSTRUCTIVE SURGERY},
   title = {Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model},
   volume = {134},
   year = {2014}
}

TY  - JOUR
ID  - 1217456
AU  - Hýža, Petr - Streit, Libor - Schwarz, Daniel - Kubek, Tomáš - Veselý, Jiří
PY  - 2014
TI  - Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model
JF  - PLASTIC AND RECONSTRUCTIVE SURGERY
VL  - 134
IS  - 4
SP  - "574E"-"584E"
EP  - "574E"-"584E"
PB  - Lippincott Williams & Wilkins
SN  - 00321052
KW  - MICROCIRCULATORY INTRAVASCULAR THROMBOSIS
KW  - ANEURYSMAL SUBARACHNOID HEMORRHAGE
KW  - MAGNESIUM-SULFATE
KW  - SKIN FLAPS
KW  - MICROVASCULAR SURGERY
KW  - CONSCIOUS RATS
KW  - METHYL-ESTER
KW  - TOPICAL USE
KW  - IN-VITRO
KW  - ISCHEMIA
N2  - Background: There has been no review study published yet comparing the effects of the vasodilating drugs that are most often used in clinical practice empirically. The aim of the authors' study was to perform this comparison and to select the drugs that are able to release vasospasm and the drugs that reduce vasospasm duration most effectively in an experimental model in vivo. Methods: Pedicled groin flaps were dissected in 300 male Wistar rats. Vasospasm was induced by tension applied on the pedicle in the axial direction using a 15-g weight. The blood perfusion of the flap was monitored using a laser Doppler device. The duration of vasospasm was defined as the time from the release of tension until blood flow began to rise. These times were detected using automated computerized detection. The effects of 11 different drugs were studied in 14 groups. The drugs were applied locally; some of them were tested in different concentrations or applied parenterally. Results: Ten percent magnesium sulfate reduced the duration of vasospasm most effectively (p < 0.01). Verapamil applied locally and also pentoxifylline applied parenterally were also very effective. In contrast, the duration of vasospasm was extended after local application of 2% lidocaine (p < 0.01). Conclusions: The authors concluded that 10% magnesium sulfate applied locally has the best ability to relieve surgically induced vasospasm because of the highest level of significance and reliability. The finding that local application of 2% lidocaine prolongs vasospasm may be surprising.
ER  -

HÝŽA, Petr; Libor STREIT; Daniel SCHWARZ; Tomáš KUBEK a Jiří VESELÝ. Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model. \textit{PLASTIC AND RECONSTRUCTIVE SURGERY}. Philadelphia: Lippincott Williams \&{} Wilkins, 2014, roč.~134, č.~4, s.~''574E''-''584E'', 11 s. ISSN~0032-1052. Dostupné z: https://doi.org/10.1097/PRS.0000000000000570.

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