Successful use of metronomic vinblastine and fluorothymidine
pet imaging for the management of intramedullary spinal cord
anaplastic oligoastrocytoma in a child

J 2014

Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

DEMLOVÁ, Regina; Kristýna MELICHÁRKOVÁ; Zdeněk ŘEHÁK; Leoš KŘEN; Hana OŠLEJŠKOVÁ et. al.

Základní údaje

Originální název

Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

Autoři

DEMLOVÁ, Regina; Kristýna MELICHÁRKOVÁ; Zdeněk ŘEHÁK; Leoš KŘEN; Hana OŠLEJŠKOVÁ a Jaroslav ŠTĚRBA

Vydání

Current Oncology, Toronto, Multimed INC. 2014, 1198-0052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.785

Kód RIV

RIV/00216224:14110/14:00078991

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3747/co.21.2147

UT WoS

000348599900008

EID Scopus

2-s2.0-84916222071

Klíčová slova anglicky

Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 3. 2015 11:39, Soňa Böhmová

Anotace

V originále

Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.

Návaznosti

LM2011017, projekt VaV

Název: Advanced Cell Immunotherapy Unit - ACIU

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Advanced cell immunotherapy unit BVI-ACIU

Citovat

DEMLOVÁ, Regina; Kristýna MELICHÁRKOVÁ; Zdeněk ŘEHÁK; Leoš KŘEN; Hana OŠLEJŠKOVÁ a Jaroslav ŠTĚRBA. Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child. Current Oncology. Toronto: Multimed INC., 2014, roč. 21, č. 6, s. "E790"-"E793", 4 s. ISSN 1198-0052. Dostupné z: https://doi.org/10.3747/co.21.2147.

@article{1220489,
   author = {Demlová, Regina and Melichárková, Kristýna and Řehák, Zdeněk and Křen, Leoš and Ošlejšková, Hana and Štěrba, Jaroslav},
   article_location = {Toronto},
   article_number = {6},
   doi = {https://doi.org/10.3747/co.21.2147},
   keywords = {Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine},
   language = {eng},
   issn = {1198-0052},
   journal = {Current Oncology},
   title = {Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child},
   volume = {21},
   year = {2014}
}

TY  - JOUR
ID  - 1220489
AU  - Demlová, Regina - Melichárková, Kristýna - Řehák, Zdeněk - Křen, Leoš - Ošlejšková, Hana - Štěrba, Jaroslav
PY  - 2014
TI  - Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child
JF  - Current Oncology
VL  - 21
IS  - 6
SP  - "E790"-"E793"
EP  - "E790"-"E793"
PB  - Multimed INC.
SN  - 11980052
KW  - Biomarkers
KW  - Metronomic chemotherapy
KW  - Pediatric glioma
KW  - PET imaging
KW  - Vinblastine
N2  - Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
ER  -

DEMLOVÁ, Regina; Kristýna MELICHÁRKOVÁ; Zdeněk ŘEHÁK; Leoš KŘEN; Hana OŠLEJŠKOVÁ a Jaroslav ŠTĚRBA. Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child. \textit{Current Oncology}. Toronto: Multimed INC., 2014, roč.~21, č.~6, s.~''E790''-''E793'', 4 s. ISSN~1198-0052. Dostupné z: https://doi.org/10.3747/co.21.2147.

Přehled o publikaci