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@article{1225458, author = {Krzyžánková, Miroslava and Chovanová, Silvia and Chlapek, Petr and Rádsetoulal, Matěj and Neradil, Jakub and Zitterbart, Karel and Štěrba, Jaroslav and Veselská, Renata}, article_location = {Dordrecht}, article_number = {8}, doi = {http://dx.doi.org/10.1007/s13277-014-2019-5}, keywords = {osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation}, language = {eng}, issn = {1010-4283}, journal = {Tumor Biology}, title = {LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.}, url = {http://link.springer.com/article/10.1007%2Fs13277-014-2019-5}, volume = {35}, year = {2014} }
TY - JOUR ID - 1225458 AU - Krzyžánková, Miroslava - Chovanová, Silvia - Chlapek, Petr - Rádsetoulal, Matěj - Neradil, Jakub - Zitterbart, Karel - Štěrba, Jaroslav - Veselská, Renata PY - 2014 TI - LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. JF - Tumor Biology VL - 35 IS - 8 SP - 7617-7627 EP - 7617-7627 PB - Springer SN - 10104283 KW - osteosarcoma KW - all-trans retinoic acid KW - caffeic acid KW - celecoxib KW - osteogenic differentiation UR - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5 L2 - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5 N2 - In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors. ER -
KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL, Karel ZITTERBART, Jaroslav ŠTĚRBA a Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. \textit{Tumor Biology}. Dordrecht: Springer, 2014, roč.~35, č.~8, s.~7617-7627. ISSN~1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-014-2019-5.
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