What level of estrogenic activity determined by in vitro assays
in municipal waste waters can be considered as safe?

J 2014

What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?

JAROŠOVÁ, Barbora; Luděk BLÁHA; JP GIESY a Klára HILSCHEROVÁ

Základní údaje

Originální název

What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?

Autoři

JAROŠOVÁ, Barbora; Luděk BLÁHA; JP GIESY a Klára HILSCHEROVÁ

Vydání

Environment International, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2014, 0160-4120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.559

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/14:00074427

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Estrogen; Threshold; In vitro assay; Environmental risk assessment; Waste water treatment plant

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 3. 2015 15:30, Ing. Filip Vaculovič

Anotace

V originále

In vitro assays are broadly used tools to evaluate the estrogenic activity in Waste Water Treatment Plant (WWTP) effluents and their receiving rivers. Since potencies of individual estrogens to induce in vitro and in vivo responses can differ it is not possible to directly evaluate risks based on in vitro measures of estrogenic activity. Estrone, 17beta-estradiol, 17alfa-ethinylestradiol and to some extent, estriol have been shown to be responsible for the majority of in vitro estrogenic activity of municipal WWTP effluents. Therefore, in the present study safe concentrations of Estrogenic Equivalents (EEQs-SSE) in municipal WWTP effluents were derived based on simplified assumption that the steroid estrogens are responsible for all estrogenicity determined with particular in vitro assays. EEQs-SSEs were derived using the bioassay and testing protocol-specific in vitro potencies of steroid estrogens, in vivo predicted no effect concentration (PNECs) of these compounds, and their relative contributions to the overall estrogenicity detected in municipal WWTP effluents. EEQs-SSEs for 15 individual bioassays varied from 0.1 to 0.4 ng EEQ/L. The EEQs-SSEs are supposed to be increased by use of location-specific dilution factors of WWTP effluents entering receiving rivers. They are applicable to municipal wastewater and rivers close to their discharges, but not to industrial waste waters. (C) 2013 Elsevier Ltd. All rights reserved.

Návaznosti

GAP503/12/0553, projekt VaV

Název: Metabolity sinic jako potenciální endokrinní disruptory

Investor: Grantová agentura ČR, Metabolity sinic jako potenciální endokrinní disruptory

Citovat

JAROŠOVÁ, Barbora; Luděk BLÁHA; JP GIESY a Klára HILSCHEROVÁ. What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe? Environment International. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2014, roč. 64, MAR 2014, s. 98-109. ISSN 0160-4120. Dostupné z: https://doi.org/10.1016/j.envint.2013.12.009.

@article{1228751,
   author = {Jarošová, Barbora and Bláha, Luděk and Giesy, JP and Hilscherová, Klára},
   article_location = {OXFORD},
   article_number = {MAR 2014},
   doi = {https://doi.org/10.1016/j.envint.2013.12.009},
   keywords = {Estrogen; Threshold; In vitro assay; Environmental risk assessment; Waste water treatment plant},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?},
   url = {http://www.sciencedirect.com/science/article/pii/S0160412013002985},
   volume = {64},
   year = {2014}
}

TY  - JOUR
ID  - 1228751
AU  - Jarošová, Barbora - Bláha, Luděk - Giesy, JP - Hilscherová, Klára
PY  - 2014
TI  - What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?
JF  - Environment International
VL  - 64
IS  - MAR 2014
SP  - 98-109
EP  - 98-109
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 01604120
KW  - Estrogen
KW  - Threshold
KW  - In vitro assay
KW  - Environmental risk assessment
KW  - Waste water treatment plant
UR  - http://www.sciencedirect.com/science/article/pii/S0160412013002985
N2  - In vitro assays are broadly used tools to evaluate the estrogenic activity in Waste Water Treatment Plant (WWTP) effluents and their receiving rivers. Since potencies of individual estrogens to induce in vitro and in vivo responses can differ it is not possible to directly evaluate risks based on in vitro measures of estrogenic activity. Estrone, 17beta-estradiol, 17alfa-ethinylestradiol and to some extent, estriol have been shown to be responsible for the majority of in vitro estrogenic activity of municipal WWTP effluents. Therefore, in the present study safe concentrations of Estrogenic Equivalents (EEQs-SSE) in municipal WWTP effluents were derived based on simplified assumption that the steroid estrogens are responsible for all estrogenicity determined with particular in vitro assays. EEQs-SSEs were derived using the bioassay and testing protocol-specific in vitro potencies of steroid estrogens, in vivo predicted no effect concentration (PNECs) of these compounds, and their relative contributions to the overall estrogenicity detected in municipal WWTP effluents. EEQs-SSEs for 15 individual bioassays varied from 0.1 to 0.4 ng EEQ/L. The EEQs-SSEs are supposed to be increased by use of location-specific dilution factors of WWTP effluents entering receiving rivers. They are applicable to municipal wastewater and rivers close to their discharges, but not to industrial waste waters. (C) 2013 Elsevier Ltd. All rights reserved.
ER  -

JAROŠOVÁ, Barbora; Luděk BLÁHA; JP GIESY a Klára HILSCHEROVÁ. What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe? \textit{Environment International}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2014, roč.~64, MAR 2014, s.~98-109. ISSN~0160-4120. Dostupné z: https://doi.org/10.1016/j.envint.2013.12.009.

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