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@article{1230107,
author = {Bona, Mirco Dalla and Zounková, Radka and Merlanti, Roberta and Bláha, Luděk and De Liguoro, Marco},
article_location = {SAN DIEGO (USA)},
article_number = {MARCH},
doi = {http://dx.doi.org/10.1016/j.ecoenv.2014.11.018},
keywords = {Daphnia magna; Fluoroquinolones; Trimethoprim; Transgenerational toxicity},
language = {eng},
issn = {0147-6513},
journal = {Ecotoxicology and Environmental Safety},
title = {Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna},
url = {http://www.sciencedirect.com/science/article/pii/S0147651314005302},
volume = {113},
year = {2015}
}
TY - JOUR
ID - 1230107
AU - Bona, Mirco Dalla - Zounková, Radka - Merlanti, Roberta - Bláha, Luděk - De Liguoro, Marco
PY - 2015
TI - Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna
JF - Ecotoxicology and Environmental Safety
VL - 113
IS - MARCH
SP - 152-158
EP - 152-158
PB - Academic Press
SN - 01476513
KW - Daphnia magna
KW - Fluoroquinolones
KW - Trimethoprim
KW - Transgenerational toxicity
UR - http://www.sciencedirect.com/science/article/pii/S0147651314005302
L2 - http://www.sciencedirect.com/science/article/pii/S0147651314005302
N2 - Multigenerational tests on Daphnia magna were performed exposing two subsequent generation to enrofloxacin (EFX) and its metabolite ciprofloxacin (CPX), and to trimethoprim (TMP). Mortality rate of 100% and 50% was detected in F0 at concentrations of >= 13 mg L-1 (EFX) and 50 mg L-1 (TMP), respectively. In F1 with respect to FO, both for growth and reproduction, a worsening trend of the response with EFX, a similar response with CPX and an attenuating trend with TMP was observed. Furthermore, the lowest EC20 for reproduction inhibition (1.3 mg L-1) was calculated for F1 exposed to EFX. However, other experimentations, longer and more complex, are necessary in order to confirm that EFX is more hazardous to daphnids than CPX and TMP. EC50 measured for the three assayed antibacterials were in the 6.5-37 mg L-1 range therefore environmental unrealistic, except in case of exceptional contaminations that may occur in relation to poorly controlled wastewaters from pharmaceutical factories or excessive use of prophylactic treatments in aquaculture.
ER -
BONA, Mirco Dalla, Radka ZOUNKOVÁ, Roberta MERLANTI, Luděk BLÁHA a Marco DE LIGUORO. Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna. \textit{Ecotoxicology and Environmental Safety}. SAN DIEGO (USA): Academic Press, roč.~113, MARCH, s.~152-158. ISSN~0147-6513. doi:10.1016/j.ecoenv.2014.11.018. 2015.
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