Wnt-regulated dynamics of positional information in zebrafish
somitogenesis

J 2014

Wnt-regulated dynamics of positional information in zebrafish somitogenesis

BAJARD-EŠNER, Lola, L.G. MORELLI, S. ARES, J. PECREAUX, F. JULICHER et. al.

Basic information

Original name

Wnt-regulated dynamics of positional information in zebrafish somitogenesis

Authors

BAJARD-EŠNER, Lola (250 France, guarantor, belonging to the institution), L.G. MORELLI (276 Germany), S. ARES (276 Germany), J. PECREAUX (276 Germany), F. JULICHER (276 Germany) and A.C. OATES (276 Germany)

Edition

Development, Cambridge, Company of Biologists, 2014, 0950-1991

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.462

RIV identification code

RIV/00216224:14740/14:00079901

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1242/dev.093435

UT WoS

000332535400021

Keywords in English

Fgf signaling; Wnt signaling; Embryonic elongation; Segmentation clock; Signal gradient; Time-lapse microscopy

Abstract

V originále

How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.

Citovat

BAJARD-EŠNER, Lola, L.G. MORELLI, S. ARES, J. PECREAUX, F. JULICHER and A.C. OATES. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development. Cambridge: Company of Biologists, 2014, vol. 141, No 6, p. 1381-1391. ISSN 0950-1991. Available from: https://dx.doi.org/10.1242/dev.093435.

@article{1232471,
   author = {BajardandEšner, Lola and Morelli, L.G. and Ares, S. and Pecreaux, J. and Julicher, F. and Oates, A.C.},
   article_location = {Cambridge},
   article_number = {6},
   doi = {http://dx.doi.org/10.1242/dev.093435},
   keywords = {Fgf signaling; Wnt signaling; Embryonic elongation; Segmentation clock; Signal gradient; Time-lapse microscopy},
   language = {eng},
   issn = {0950-1991},
   journal = {Development},
   title = {Wnt-regulated dynamics of positional information in zebrafish somitogenesis},
   url = {http://dev.biologists.org/content/141/6/1381.long},
   volume = {141},
   year = {2014}
}

TY  - JOUR
ID  - 1232471
AU  - Bajard-Ešner, Lola - Morelli, L.G. - Ares, S. - Pecreaux, J. - Julicher, F. - Oates, A.C.
PY  - 2014
TI  - Wnt-regulated dynamics of positional information in zebrafish somitogenesis
JF  - Development
VL  - 141
IS  - 6
SP  - 1381-1391
EP  - 1381-1391
PB  - Company of Biologists
SN  - 09501991
KW  - Fgf signaling
KW  - Wnt signaling
KW  - Embryonic elongation
KW  - Segmentation clock
KW  - Signal gradient
KW  - Time-lapse microscopy
UR  - http://dev.biologists.org/content/141/6/1381.long
L2  - http://dev.biologists.org/content/141/6/1381.long
N2  - How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
ER  -

BAJARD-EŠNER, Lola, L.G. MORELLI, S. ARES, J. PECREAUX, F. JULICHER and A.C. OATES. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. \textit{Development}. Cambridge: Company of Biologists, 2014, vol.~141, No~6, p.~1381-1391. ISSN~0950-1991. Available from: https://dx.doi.org/10.1242/dev.093435.

Detailed Information on Publication Record