2015
THE EFFECT OF GLUCOSE VARIABILITY ON THE EXPRESSION OF GENES INVOLVED IN HYPERGLYCAEMIA-INDUCED TISSUE DAMAGE
PÁCAL, Lukáš, Katarína KURICOVÁ, Jan ŠOUPAL, Martin PRÁZNÝ, Kateřina KAŇKOVÁ et. al.Základní údaje
Originální název
THE EFFECT OF GLUCOSE VARIABILITY ON THE EXPRESSION OF GENES INVOLVED IN HYPERGLYCAEMIA-INDUCED TISSUE DAMAGE
Název anglicky
THE EFFECT OF GLUCOSE VARIABILITY ON THE EXPRESSION OF GENES INVOLVED IN HYPERGLYCAEMIA-INDUCED TISSUE DAMAGE
Autoři
Vydání
12th International Symposium on the Maillard Reaction (IMARS), 2015
Další údaje
Typ výsledku
Konferenční abstrakt
Utajení
není předmětem státního či obchodního tajemství
Klíčová slova anglicky
glycaemic variability, hyperglycaemia, antioxidant enzymes
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 22. 9. 2015 15:37, Mgr. Lukáš Pácal, Ph.D.
Anotace
V originále
Large prospective studies provided evidence of the relationship between long-term diabetes compensation expressed as HbA1c and the risk of diabetic cardiovascular complications. However, HbA1c and diabetes duration explain only small portion of the complications risk. Patients with the same HbA1c differ in amplitudes and duration of glycaemic excursions (so called glucose variability [GV]). Limited number of animal and in vitro studies showed that oscillating glucose may have more deleterious effect on cells than hyperglycaemia itself. Therefore, the aim of our study was to evaluate the effect of GV on the expression of genes whose products are involved in the development and protection against tissue damage in diabetes. Specifically, we measured gene expression of glyoxalase 1 (GLO1), and other enzymes with antioxidant activity – hemoxygenase (HMOX), superoxide dismutase 2 (SOD2) and enzyme with putative glyoxalase activity DJ1 in vitro.
Návaznosti
| NT13198, projekt VaV |
|