Regulatory B cells in CVID patients fail to suppress
multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells
differentiation

J 2015

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation

VLKOVÁ, Marcela; Olga TICHÁ; Jana NECHVÁTALOVÁ; Tomas KALINA; Jiří LITZMAN et al.

Základní údaje

Originální název

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation

Autoři

VLKOVÁ, Marcela; Olga TICHÁ; Jana NECHVÁTALOVÁ; Tomas KALINA; Jiří LITZMAN; Claudia MAURI a Paul A. BLAIR

Vydání

Clinical Immunology, San Diego, Academic Press Inc. Elsevier Science, 2015, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.034

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00084180

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 11. 2015 15:07, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

Citovat

VLKOVÁ, Marcela; Olga TICHÁ; Jana NECHVÁTALOVÁ; Tomas KALINA; Jiří LITZMAN; Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. Clinical Immunology. San Diego: Academic Press Inc. Elsevier Science, 2015, roč. 160, č. 2, s. 292-300. ISSN 1521-6616. Dostupné z: https://doi.org/10.1016/j.clim.2015.06.013.

@article{1313280,
   author = {Vlková, Marcela and Tichá, Olga and Nechvátalová, Jana and Kalina, Tomas and Litzman, Jiří and Mauri, Claudia and Blair, Paul A.},
   article_location = {San Diego},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.clim.2015.06.013},
   keywords = {B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell},
   language = {eng},
   issn = {1521-6616},
   journal = {Clinical Immunology},
   title = {Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation},
   volume = {160},
   year = {2015}
}

TY  - JOUR
ID  - 1313280
AU  - Vlková, Marcela - Tichá, Olga - Nechvátalová, Jana - Kalina, Tomas - Litzman, Jiří - Mauri, Claudia - Blair, Paul A.
PY  - 2015
TI  - Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation
JF  - Clinical Immunology
VL  - 160
IS  - 2
SP  - 292-300
EP  - 292-300
PB  - Academic Press Inc. Elsevier Science
SN  - 15216616
KW  - B cell
KW  - Common variable immunodeficiency (CVID)
KW  - Cytokine production
KW  - Flow cytometry
KW  - T cell
N2  - Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.
ER  -

VLKOVÁ, Marcela; Olga TICHÁ; Jana NECHVÁTALOVÁ; Tomas KALINA; Jiří LITZMAN; Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. \textit{Clinical Immunology}. San Diego: Academic Press Inc. Elsevier Science, 2015, roč.~160, č.~2, s.~292-300. ISSN~1521-6616. Dostupné z: https://doi.org/10.1016/j.clim.2015.06.013.

Přehled o publikaci