Regulatory B cells in CVID patients fail to suppress
multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells
differentiation

J 2015

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation

VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN et. al.

Základní údaje

Originální název

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation

Autoři

VLKOVÁ, Marcela (203 Česká republika, domácí), Olga TICHÁ (203 Česká republika, domácí), Jana NECHVÁTALOVÁ (203 Česká republika, domácí), Tomas KALINA (203 Česká republika), Jiří LITZMAN (203 Česká republika, domácí), Claudia MAURI (203 Česká republika) a Paul A. BLAIR (826 Velká Británie a Severní Irsko)

Vydání

Clinical Immunology, San Diego, Academic Press Inc. Elsevier Science, 2015, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.034

Kód RIV

RIV/00216224:14110/15:00084180

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.clim.2015.06.013

UT WoS

000362151500019

Klíčová slova anglicky

B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 11. 2015 15:07, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

Citovat

VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. Clinical Immunology. San Diego: Academic Press Inc. Elsevier Science, 2015, roč. 160, č. 2, s. 292-300. ISSN 1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2015.06.013.

@article{1313280,
   author = {Vlková, Marcela and Tichá, Olga and Nechvátalová, Jana and Kalina, Tomas and Litzman, Jiří and Mauri, Claudia and Blair, Paul A.},
   article_location = {San Diego},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.clim.2015.06.013},
   keywords = {B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell},
   language = {eng},
   issn = {1521-6616},
   journal = {Clinical Immunology},
   title = {Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation},
   volume = {160},
   year = {2015}
}

TY  - JOUR
ID  - 1313280
AU  - Vlková, Marcela - Tichá, Olga - Nechvátalová, Jana - Kalina, Tomas - Litzman, Jiří - Mauri, Claudia - Blair, Paul A.
PY  - 2015
TI  - Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation
JF  - Clinical Immunology
VL  - 160
IS  - 2
SP  - 292-300
EP  - 292-300
PB  - Academic Press Inc. Elsevier Science
SN  - 15216616
KW  - B cell
KW  - Common variable immunodeficiency (CVID)
KW  - Cytokine production
KW  - Flow cytometry
KW  - T cell
N2  - Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.
ER  -

VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. \textit{Clinical Immunology}. San Diego: Academic Press Inc. Elsevier Science, 2015, roč.~160, č.~2, s.~292-300. ISSN~1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2015.06.013.

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