The bioinformatic analyses of “-omes” of helminths with special
focus on serine peptidases of Eudiplozoon nipponicum

k 2014

The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum

VOREL, Jiří; Hana DVOŘÁKOVÁ; Lucie JEDLIČKOVÁ; Libor MIKEŠ; Milan GELNAR et al.

Základní údaje

Originální název

The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum

Název česky

Bioinformatické analýzy „–omů“ parazitických červů se zaměřením na serinové peptidázy Eudiplozoon nipponicum.

Autoři

VOREL, Jiří; Hana DVOŘÁKOVÁ; Lucie JEDLIČKOVÁ; Libor MIKEŠ; Milan GELNAR a Martin KAŠNÝ

Vydání

NGS workshop and conference MouseGene, 2014

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Sequencing; NGS data processing; Transcriptomics; Genetics; Helminths; Eudiplozoon nipponicum; Serine peptidases

Změněno: 16. 2. 2018 14:34, Mgr. Jiří Vorel, Ph.D.

Anotace

V originále

Parasitic helminths are causative agents of number of serious diseases (helminthiasis) of animals and people. Our understanding to the biological processes of helminths is based also on detailed knowledge of their molecular biology and biochemistry. By using the modern pyro-sequencing methods and computer databases (genomic, transcriptomic and proteomic) we can now faster and more accurately identify numerous sets of protein molecules which are essential for life of parasites. Since September 2011 the “50 Helminth Genomes Project” is running, but from a large group of Monogenea only one species is currently sequenced - Protopolystoma xenopodis. We would like to change this situation and therefore we adopted Eudiplozoon nipponicum (Monogenea: Diplozoidae) as a model organism and started some preliminary analyses leaded to generation of E. nipponicum genome, transcriptome and proteome databases. We would like to use data platforms for identification and further characterization of protein molecules involved into the interaction between host and parasite. Our preliminary transcriptome results suggest that such molecules could be serine peptidases. Serine peptidases are molecules essential for life in all organism including parasitic helminths. These molecules help them to penetrate the defensive barriers and avoid the immune attack of the host. Hematophagous parasites allows digest blood and obtain necessary nutrients.

Návaznosti

MUNI/A/0888/2013, interní kód MU

Název: Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí (Akronym: BIDA3)

Investor: Masarykova univerzita, Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

VOREL, Jiří; Hana DVOŘÁKOVÁ; Lucie JEDLIČKOVÁ; Libor MIKEŠ; Milan GELNAR a Martin KAŠNÝ. The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum. In NGS workshop and conference MouseGene. 2014.

@proceedings{1313932,
   author = {Vorel, Jiří and Dvořáková, Hana and Jedličková, Lucie and Mikeš, Libor and Gelnar, Milan and Kašný, Martin},
   booktitle = {NGS workshop and conference MouseGene},
   keywords = {Sequencing; NGS data processing; Transcriptomics; Genetics; Helminths; Eudiplozoon nipponicum; Serine peptidases},
   language = {eng},
   title = {The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum},
   year = {2014}
}

TY  - CONF
ID  - 1313932
AU  - Vorel, Jiří - Dvořáková, Hana - Jedličková, Lucie - Mikeš, Libor - Gelnar, Milan - Kašný, Martin
PY  - 2014
TI  - The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum
KW  - Sequencing
KW  - NGS data processing
KW  - Transcriptomics
KW  - Genetics
KW  - Helminths
KW  - Eudiplozoon nipponicum
KW  - Serine peptidases
N2  - Parasitic helminths are causative agents of number of serious diseases (helminthiasis) of animals and people. Our understanding to the biological processes of helminths is based also on detailed knowledge of their molecular biology and biochemistry. By using the modern pyro-sequencing methods and computer databases (genomic, transcriptomic and proteomic) we can now faster and more accurately identify numerous sets of protein molecules which are essential for life of parasites. Since September 2011 the “50 Helminth Genomes Project” is running, but from a large group of Monogenea only one species is currently sequenced - Protopolystoma xenopodis. We would like to change this situation and therefore we adopted Eudiplozoon nipponicum (Monogenea: Diplozoidae) as a model organism and started some preliminary analyses leaded to generation of E. nipponicum genome, transcriptome and proteome databases. We would like to use data platforms for identification and further characterization of protein molecules involved into the interaction between host and parasite. Our preliminary transcriptome results suggest that such molecules could be serine peptidases. Serine peptidases are molecules essential for life in all organism including parasitic helminths. These molecules help them to penetrate the defensive barriers and avoid the immune attack of the host. Hematophagous parasites allows digest blood and obtain necessary nutrients.
ER  -

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