NOVÁK, Jan, Veronika OLEJNÍČKOVÁ, Nikola TKÁČOVÁ a Gaetano SANTULLI. Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis. Advances in Experimental Medicine and Biology. New York: Springer, roč. 887, "neuvedeno", s. 79-100. ISSN 0065-2598. doi:10.1007/978-3-319-22380-3_5. 2015.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis
Autoři NOVÁK, Jan (203 Česká republika, garant, domácí), Veronika OLEJNÍČKOVÁ (203 Česká republika, domácí), Nikola TKÁČOVÁ (703 Slovensko, domácí) a Gaetano SANTULLI (840 Spojené státy).
Vydání Advances in Experimental Medicine and Biology, New York, Springer, 2015, 0065-2598.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30105 Physiology
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.953
Kód RIV RIV/00216224:14110/15:00084363
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1007/978-3-319-22380-3_5
UT WoS 000368698100006
Klíčová slova anglicky lipid metabolism; HDL; LDL; cholesterol; atherosclerosis; miR-33; miR-122; miR-223
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 29. 2. 2016 16:35.
Anotace
MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional regulators of gene expression being involved in the fine control of a plethora of physiological and pathological processes. Besides their well-established crucial roles in the regulation of cell cycle, embryogenesis or tumorigenesis, these tiny molecules have also been shown to participate in the regulation of lipid metabolism. In particular, miRs orchestrate cholesterol and fatty acids synthesis, transport, and degradation and low-density and high-density lipoprotein (LDL and HDL) formation. It is thus not surprising that they have also been reported to affect the development and progression of several lipid metabolism-related disorders including liver steatosis and atherosclerosis. Mounting evidence suggests that miRs might represent important “posttranscriptional hubs” of lipid metabolism, which means that one miR usually targets 3’-untranslated regions of various mRNAs that are involved in different steps of one precise metabolic/signaling pathway, e.g., one miR targets mRNAs of enzymes important for cholesterol synthesis, degradation, and transport. Therefore, changes in the levels of one key miR affect various steps of one pathway, which is thereby promoted or inhibited. This makes miRs potent future diagnostic and even therapeutic tools for personalized medicine. Within this chapter, the most prominent microRNAs involved in lipid metabolism, e.g., miR-27a/b, miR-33/33*, miR-122, miR-144, or miR-223, and their intracellular and extracellular functions will be extensively discussed, in particular focusing on their mechanistic role in the pathophysiology of atherosclerosis. Special emphasis will be given on miR-122, the first microRNA currently in clinical trials for the treatment of hepatitis C and on miR-223, the most abundant miR in lipoprotein particles.
Návaznosti
MUNI/A/1326/2014, interní kód MUNázev: Kardiovaskulární systém od buňky k lůžku pacienta (Akronym: KASBUNPAC)
Investor: Masarykova univerzita, Kardiovaskulární systém od buňky k lůžku pacienta, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty
VytisknoutZobrazeno: 28. 3. 2024 14:22