The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T,
Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and
Long-Term Outcome in Patients with Coronary Artery Disease

J 2015

The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

KINCL, Vladimír; Jan MÁCHAL; Adéla DROZDOVÁ; Roman PANOVSKÝ; Anna VAŠKŮ et al.

Základní údaje

Originální název

The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

Autoři

KINCL, Vladimír; Jan MÁCHAL; Adéla DROZDOVÁ; Roman PANOVSKÝ a Anna VAŠKŮ

Vydání

Disease Markers, New York, Hindawi Publishing Corporation, 2015, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.137

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00084563

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

endothelial nitric oxide synthase; matrix metaloproteinase; eotaxin; gene polymorphism; coronary artery disease; survival

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 1. 2016 11:50, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion. The A allele in eotaxin 67G/Apolymorphismis associated with worse survival in CAD patients.

Citovat

KINCL, Vladimír; Jan MÁCHAL; Adéla DROZDOVÁ; Roman PANOVSKÝ a Anna VAŠKŮ. The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. New York: Hindawi Publishing Corporation, 2015, roč. 2015, September, s. 1-7. ISSN 0278-0240. Dostupné z: https://doi.org/10.1155/2015/232048.

@article{1316154,
   author = {Kincl, Vladimír and Máchal, Jan and Drozdová, Adéla and Panovský, Roman and Vašků, Anna},
   article_location = {New York},
   article_number = {September},
   doi = {https://doi.org/10.1155/2015/232048},
   keywords = {endothelial nitric oxide synthase; matrix metaloproteinase; eotaxin; gene polymorphism; coronary artery disease; survival},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease},
   url = {http://www.hindawi.com/journals/dm/2015/232048/},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1316154
AU  - Kincl, Vladimír - Máchal, Jan - Drozdová, Adéla - Panovský, Roman - Vašků, Anna
PY  - 2015
TI  - The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease
JF  - Disease Markers
VL  - 2015
IS  - September
SP  - 1-7
EP  - 1-7
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - endothelial nitric oxide synthase
KW  - matrix metaloproteinase
KW  - eotaxin
KW  - gene polymorphism
KW  - coronary artery disease
KW  - survival
UR  - http://www.hindawi.com/journals/dm/2015/232048/
N2  - Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion. The A allele in eotaxin 67G/Apolymorphismis associated with worse survival in CAD patients.
ER  -

KINCL, Vladimír; Jan MÁCHAL; Adéla DROZDOVÁ; Roman PANOVSKÝ a Anna VAŠKŮ. The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. \textit{Disease Markers}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, September, s.~1-7. ISSN~0278-0240. Dostupné z: https://doi.org/10.1155/2015/232048.

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