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@article{1319734,
author = {Kaspar, Petr and Zikova, Martina and Bartunek, Petr and Štěrba, Jaroslav and Strnad, Hynek and Křen, Leoš and Sedlacek, Radislav},
article_location = {London},
article_number = {15090},
doi = {http://dx.doi.org/10.1038/srep15090},
keywords = {CELL-DIFFERENTIATION; PEDIATRIC RHABDOMYOSARCOMAS; GENE-EXPRESSION; DOWN-REGULATION; CANCER-CELLS; PROLIFERATION; MICRORNAS; SURVIVAL; LEUKEMIA; INVASION},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin},
volume = {5},
year = {2015}
}
TY - JOUR
ID - 1319734
AU - Kaspar, Petr - Zikova, Martina - Bartunek, Petr - Štěrba, Jaroslav - Strnad, Hynek - Křen, Leoš - Sedlacek, Radislav
PY - 2015
TI - The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin
JF - Scientific Reports
VL - 5
IS - 15090
SP - 1-10
EP - 1-10
PB - Nature Publishing Group
SN - 20452322
KW - CELL-DIFFERENTIATION
KW - PEDIATRIC RHABDOMYOSARCOMAS
KW - GENE-EXPRESSION
KW - DOWN-REGULATION
KW - CANCER-CELLS
KW - PROLIFERATION
KW - MICRORNAS
KW - SURVIVAL
KW - LEUKEMIA
KW - INVASION
N2 - The transcription factor c-Myb is required for modulation of progenitor cells in several tissues, including skeletal muscle and its upregulation is observed in many human malignancies. Rhabdomyosarcomas (RMS) are a heterogeneous group of mesodermal tumors with features of developing skeletal muscle. Several miRNAs are downregulated in RMS, including miR-150, a negative regulator of c-Myb expression. Using the C2C12 myoblast cell line, a cellular model of skeletal muscle differentiation, we showed that miR-150 controls c-Myb expression mainly at the level of translation. We hypothesized that a similar mechanism of c-Myb regulation operates in RMS tumors. We examined expression of c-Myb by immunohistochemistry and revealed c-Myb positivity in alveolar and embryonal tumors, the two most common subgroups of RMS. Furthermore, we showed direct correlation between c-Myb production and myogenin expression. Interestingly, high myogenin levels indicate poor prognosis in RMS patients. c-Myb could, therefore, contribute to the tumor phenotype by executing its inhibitory role in skeletal muscle differentiation. We also showed that c-Myb protein is abundant in migratory C2C12 myoblasts and its ectopic expression potentiates cell motility. In summary, our results implicate that metastatic properties of some RMS subtypes might be linked to c-Myb function.
ER -
KASPAR, Petr, Martina ZIKOVA, Petr BARTUNEK, Jaroslav ŠTĚRBA, Hynek STRNAD, Leoš KŘEN a Radislav SEDLACEK. The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin. \textit{Scientific Reports}. London: Nature Publishing Group, 2015, roč.~5, č.~15090, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep15090.
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