Langerhans cell histiocytosis: intrinsic immunoediting
properties

a 2015

Langerhans cell histiocytosis: intrinsic immunoediting properties

KŘENOVÁ, Zdenka; Eliška TVRDÍKOVÁ; Jaroslav ŠTĚRBA; Daniela KODYTKOVÁ; Leoš KŘEN et al.

Základní údaje

Originální název

Langerhans cell histiocytosis: intrinsic immunoediting properties

Autoři

KŘENOVÁ, Zdenka; Eliška TVRDÍKOVÁ; Jaroslav ŠTĚRBA; Daniela KODYTKOVÁ a Leoš KŘEN

Vydání

XXV. Konference dětských hematologů a onkologů České a Slovenské republiky, 2015

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00085104

Organizační jednotka

Lékařská fakulta

ISBN

978-80-210-7958-8

Klíčová slova anglicky

langerhans cell histiocytosis; non-classical immunomodulatory molecules; intrinsic immunoediting properties

Štítky

EL OK

Změněno: 7. 12. 2015 14:58, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Non-classical HLA-molecules physiologically protect the fetus from maternal allorecognition, this mechanism seems to be used by some tumors during their development. PD-L1 is physiologically expressed mainly on antigen presenting cells, some types of tumors use this ligand to supress host immune reactions. The expression of non-classical immunomodulatory molecules (HLA-G, HLA-E, HLA-F) as well as the expression of immune checkpoint regulator programmed death ligand (PD-L1) is not characterized in Langerhans cell histiocytosis (LCH). Our data suggest that non-classical immunomodulatory molecules and immune checkpoint molecules may play role in immunoediting process during development of LCH. Further studies regarding immunoediting properties including non-classical HLA molecules and immune checkpoints ligands appear warranted for better understanding and therapy of this enigmatic disorder.

Citovat

KŘENOVÁ, Zdenka; Eliška TVRDÍKOVÁ; Jaroslav ŠTĚRBA; Daniela KODYTKOVÁ a Leoš KŘEN. Langerhans cell histiocytosis: intrinsic immunoediting properties. In XXV. Konference dětských hematologů a onkologů České a Slovenské republiky. 2015. ISBN 978-80-210-7958-8.

@proceedings{1320366,
   author = {Křenová, Zdenka and Tvrdíková, Eliška and Štěrba, Jaroslav and Kodytková, Daniela and Křen, Leoš},
   booktitle = {XXV. Konference dětských hematologů a onkologů České a Slovenské republiky},
   keywords = {langerhans cell histiocytosis; non-classical immunomodulatory molecules; intrinsic immunoediting properties},
   language = {eng},
   isbn = {978-80-210-7958-8},
   title = {Langerhans cell histiocytosis: intrinsic immunoediting properties},
   year = {2015}
}

TY  - CONF
ID  - 1320366
AU  - Křenová, Zdenka - Tvrdíková, Eliška - Štěrba, Jaroslav - Kodytková, Daniela - Křen, Leoš
PY  - 2015
TI  - Langerhans cell histiocytosis: intrinsic immunoediting properties
SN  - 9788021079588
KW  - langerhans cell histiocytosis
KW  - non-classical immunomodulatory molecules
KW  - intrinsic immunoediting properties
N2  - Non-classical HLA-molecules physiologically protect the fetus from maternal allorecognition, this mechanism seems to be used by some tumors during their development. PD-L1 is physiologically expressed mainly on antigen presenting cells, some types of tumors use this ligand to supress host immune reactions. The expression of non-classical immunomodulatory molecules (HLA-G, HLA-E, HLA-F) as well as the expression of immune checkpoint regulator programmed death ligand (PD-L1) is not characterized in Langerhans cell histiocytosis (LCH). Our data suggest that non-classical immunomodulatory molecules and immune checkpoint molecules may play role in immunoediting process during development of LCH. Further studies regarding immunoediting properties including non-classical HLA molecules and immune checkpoints ligands appear warranted for better understanding and therapy of this enigmatic disorder.
ER  -

KŘENOVÁ, Zdenka; Eliška TVRDÍKOVÁ; Jaroslav ŠTĚRBA; Daniela KODYTKOVÁ a Leoš KŘEN. Langerhans cell histiocytosis: intrinsic immunoediting properties. In \textit{XXV. Konference dětských hematologů a onkologů České a Slovenské republiky}. 2015. ISBN~978-80-210-7958-8.

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