Serum carboxymethyl-lysine, a dominant advanced glycation end
product, is increased in women with gestational diabetes
mellitus

J 2016

Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus

BARTÁKOVÁ, Vendula; Radana KOLLAROVA; Katarína KURICOVÁ; Katarina SEBEKOVA; Jana BELOBRADKOVA et al.

Základní údaje

Originální název

Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus

Autoři

BARTÁKOVÁ, Vendula ; Radana KOLLAROVA; Katarína KURICOVÁ; Katarina SEBEKOVA; Jana BELOBRADKOVA a Kateřina KAŇKOVÁ

Vydání

Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Palacký University, 2016, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.894

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00088835

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

gestational diabetes; CML; BMI; oral glucose tolerance test; postpartum glucose intole

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 8. 2016 16:05, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Aims: The objective of the study was to measure one of the circulating Advanced Glycation End Products (AGEs) - N-(carboxymethyl)lysine (CML) - in a case-control study (n = 307) of pregnant women with gestational diabetes mellitus (GDM) and physiological pregnancies and to ascertain the factors contributing to CML levels and the potential relevance of CML for selected perinatal and postpartum outcomes. Methods: All subjects underwent oGTT between 24th and 30th week of gestation and GDM was diagnosed according to WHO criteria. CML was determined by ELISA using commercial kit. Results: Unadjusted and plasma protein adjusted CML levels were significantly higher in women with GDM compared to healthy controls (P = 0.00043 and P = 1x10-5, respectively, Mann-Whitney). CML was significantly inversely correlated with both pre- and mid-gestational BMI, however, differences between GDM and control group remained significant even after adjustment for BMI. CML levels correlated with 1-h and 2-h post-load glycaemia during oGTT. Conclusion: In conclusion, we found statistically significantly higher protein- and BMI-normalised CML levels measured during 24-30th week of gestation in women with GDM compared to healthy pregnant controls. Further studies are warranted to comprehensively asses the spectrum of AGEs in GDM and their relevance to future metabolic health of mother and offspring.

Návaznosti

NT11405, projekt VaV

Název: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministerstvo zdravotnictví ČR, Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Citovat

BARTÁKOVÁ, Vendula; Radana KOLLAROVA; Katarína KURICOVÁ; Katarina SEBEKOVA; Jana BELOBRADKOVA a Kateřina KAŇKOVÁ. Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus. Biomedical Papers of the Faculty of Medicine of Palacký University. Olomouc: Palacký University, 2016, roč. 160, č. 1, s. 70-75. ISSN 1213-8118. Dostupné z: https://doi.org/10.5507/bp.2015.045.

@article{1320391,
   author = {Bartáková, Vendula and Kollarova, Radana and Kuricová, Katarína and Sebekova, Katarina and Belobradkova, Jana and Kaňková, Kateřina},
   article_location = {Olomouc},
   article_number = {1},
   doi = {https://doi.org/10.5507/bp.2015.045},
   keywords = {gestational diabetes; CML; BMI; oral glucose tolerance test; postpartum glucose intole},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers of the Faculty of Medicine of Palacký University},
   title = {Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus},
   volume = {160},
   year = {2016}
}

TY  - JOUR
ID  - 1320391
AU  - Bartáková, Vendula - Kollarova, Radana - Kuricová, Katarína - Sebekova, Katarina - Belobradkova, Jana - Kaňková, Kateřina
PY  - 2016
TI  - Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus
JF  - Biomedical Papers of the Faculty of Medicine of Palacký University
VL  - 160
IS  - 1
SP  - 70-75
EP  - 70-75
PB  - Palacký University
SN  - 12138118
KW  - gestational diabetes
KW  - CML
KW  - BMI
KW  - oral glucose tolerance test
KW  - postpartum glucose intole
N2  - Aims: The objective of the study was to measure one of the circulating Advanced Glycation End Products (AGEs) - N-(carboxymethyl)lysine (CML) - in a case-control study (n = 307) of pregnant women with gestational diabetes mellitus (GDM) and physiological pregnancies and to ascertain the factors contributing to CML levels and the potential relevance of CML for selected perinatal and postpartum outcomes. Methods: All subjects underwent oGTT between 24th and 30th week of gestation and GDM was diagnosed according to WHO criteria. CML was determined by ELISA using commercial kit. Results: Unadjusted and plasma protein adjusted CML levels were significantly higher in women with GDM compared to healthy controls (P = 0.00043 and P = 1x10-5, respectively, Mann-Whitney). CML was significantly inversely correlated with both pre- and mid-gestational BMI, however, differences between GDM and control group remained significant even after adjustment for BMI. CML levels correlated with 1-h and 2-h post-load glycaemia during oGTT. Conclusion: In conclusion, we found statistically significantly higher protein- and BMI-normalised CML levels measured during 24-30th week of gestation in women with GDM compared to healthy pregnant controls. Further studies are warranted to comprehensively asses the spectrum of AGEs in GDM and their relevance to future metabolic health of mother and offspring.
ER  -

BARTÁKOVÁ, Vendula; Radana KOLLAROVA; Katarína KURICOVÁ; Katarina SEBEKOVA; Jana BELOBRADKOVA a Kateřina KAŇKOVÁ. Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus. \textit{Biomedical Papers of the Faculty of Medicine of Palacký University}. Olomouc: Palacký University, 2016, roč.~160, č.~1, s.~70-75. ISSN~1213-8118. Dostupné z: https://doi.org/10.5507/bp.2015.045.

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