| KAŠPAROVÁ, Helena, Zuzana DVOŘÁKOVÁ, Daniel RENČIUK, Klára BEDNÁŘOVÁ, Iva KEJNOVSKÁ, Lukáš TRANTÍREK, Michaela VORLÍČKOVÁ a Janos SAGI. Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex. Biochimie. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2015, roč. 118, Nov, s. 15-25. ISSN 0300-9084. Dostupné z: https://dx.doi.org/10.1016/j.biochi.2015.07.013. |
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@article{1321779,
author = {Kašparová, Helena and Dvořáková, Zuzana and Renčiuk, Daniel and Bednářová, Klára and Kejnovská, Iva and Trantírek, Lukáš and Vorlíčková, Michaela and Sagi, Janos},
article_location = {Paris},
article_number = {Nov},
doi = {http://dx.doi.org/10.1016/j.biochi.2015.07.013},
keywords = {DNA secondary structure; Circular dichroism spectroscopy; Guanine quadruplex; Base modification; Oxidative damage},
language = {eng},
issn = {0300-9084},
journal = {Biochimie},
title = {Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex},
url = {http://www.sciencedirect.com/science/article/pii/S0300908415002217},
volume = {118},
year = {2015}
}
TY - JOUR
ID - 1321779
AU - Kašparová, Helena - Dvořáková, Zuzana - Renčiuk, Daniel - Bednářová, Klára - Kejnovská, Iva - Trantírek, Lukáš - Vorlíčková, Michaela - Sagi, Janos
PY - 2015
TI - Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex
JF - Biochimie
VL - 118
IS - Nov
SP - 15-25
EP - 15-25
PB - Elsevier France- editions Scientifiques Medicales Elsevier
SN - 03009084
KW - DNA secondary structure
KW - Circular dichroism spectroscopy
KW - Guanine quadruplex
KW - Base modification
KW - Oxidative damage
UR - http://www.sciencedirect.com/science/article/pii/S0300908415002217
L2 - http://www.sciencedirect.com/science/article/pii/S0300908415002217
N2 - Various base lesions continuously form in cellular nucleic acids and the unrepaired lesions are promutagenic and procarcinogenic. Though natural base lesions have been extensively studied in double-stranded DNA models, these studies are only less than a decade old for non-canonical DNA models, such as quadruplexes. Here we present a report on the effects of three frequently occurring natural lesions that can form in the TTA loops on the structure of the human telomere quadruplex d[AG(3)(TTAG(3))(3)]. We compared the effect of the abasic site and 8-oxoadenine replacing adenine and 5-hydroxymethyluracil substituting for thymine. The results showed that the three lesions impacted the stability and quadruplex folding in markedly different ways. The effects depended on the type of lesion and the position in the sequence. Analogous lesions of guanine in the G-tetrads extensively destabilized the quadruplex and the effects depended more on the position than on the type of lesion. The distinct effects of the loop substitutions as well as comparison of the modifications of the loops and the quadruplex tetrads are discussed in this communication.
ER -
KAŠPAROVÁ, Helena, Zuzana DVOŘÁKOVÁ, Daniel RENČIUK, Klára BEDNÁŘOVÁ, Iva KEJNOVSKÁ, Lukáš TRANTÍREK, Michaela VORLÍČKOVÁ a Janos SAGI. Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex. \textit{Biochimie}. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2015, roč.~118, Nov, s.~15-25. ISSN~0300-9084. Dostupné z: https://dx.doi.org/10.1016/j.biochi.2015.07.013.
|
