Hippocampal proton MR spectroscopy as a novel approach in the
assessment of radiation injury and the correlation to
neurocognitive function impairment: initial experiences

J 2015

Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences

POSPÍŠIL, Petr; Tomáš KAZDA; Martin BULIK; Marie DOBIÁŠKOVÁ; Petr BURKOŇ et al.

Základní údaje

Originální název

Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences

Autoři

POSPÍŠIL, Petr; Tomáš KAZDA; Martin BULIK; Marie DOBIÁŠKOVÁ; Petr BURKOŇ; Ludmila HYNKOVÁ; Pavel ŠLAMPA a Radim JANČÁLEK

Vydání

Radiation Oncology, London, BioMed Central, 2015, 1748-717X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.466

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00085324

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 1. 2016 10:26, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by H-1-MR spectroscopy focused on the hippocampus. Methods: Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy H-1-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Results: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. Conclusions: A significant decrease in h-tNAA after WBRT was proven by H-1-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed.

Citovat

POSPÍŠIL, Petr; Tomáš KAZDA; Martin BULIK; Marie DOBIÁŠKOVÁ; Petr BURKOŇ; Ludmila HYNKOVÁ; Pavel ŠLAMPA a Radim JANČÁLEK. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. Radiation Oncology. London: BioMed Central, 2015, roč. 10, č. 211, s. 1-8. ISSN 1748-717X. Dostupné z: https://doi.org/10.1186/s13014-015-0518-1.

@article{1321781,
   author = {Pospíšil, Petr and Kazda, Tomáš and Bulik, Martin and Dobiášková, Marie and Burkoň, Petr and Hynková, Ludmila and Šlampa, Pavel and Jančálek, Radim},
   article_location = {London},
   article_number = {211},
   doi = {https://doi.org/10.1186/s13014-015-0518-1},
   keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
   language = {eng},
   issn = {1748-717X},
   journal = {Radiation Oncology},
   title = {Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1321781
AU  - Pospíšil, Petr - Kazda, Tomáš - Bulik, Martin - Dobiášková, Marie - Burkoň, Petr - Hynková, Ludmila - Šlampa, Pavel - Jančálek, Radim
PY  - 2015
TI  - Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences
JF  - Radiation Oncology
VL  - 10
IS  - 211
SP  - 1-8
EP  - 1-8
PB  - BioMed Central
SN  - 1748717X
KW  - Hippocampus
KW  - Radiation injury
KW  - Neurocognitive function
KW  - Magnetic resonance spectroscopy
N2  - Background: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by H-1-MR spectroscopy focused on the hippocampus. Methods: Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy H-1-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Results: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. Conclusions: A significant decrease in h-tNAA after WBRT was proven by H-1-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed.
ER  -

POSPÍŠIL, Petr; Tomáš KAZDA; Martin BULIK; Marie DOBIÁŠKOVÁ; Petr BURKOŇ; Ludmila HYNKOVÁ; Pavel ŠLAMPA a Radim JANČÁLEK. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. \textit{Radiation Oncology}. London: BioMed Central, 2015, roč.~10, č.~211, s.~1-8. ISSN~1748-717X. Dostupné z: https://doi.org/10.1186/s13014-015-0518-1.

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