Positive Influence of Being Overweight/Obese on Long Term
Survival in Patients Hospitalised Due to Acute Heart Failure

J 2015

Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure

LITTNEROVÁ, Simona, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Ales LINHART et. al.

Basic information

Original name

Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure

Authors

LITTNEROVÁ, Simona (203 Czech Republic, guarantor, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic), Ales LINHART (203 Czech Republic), Petr WIDIMSKÝ (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Roman MIKLÍK (203 Czech Republic), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Kamil ZEMAN (203 Czech Republic), Jan BELOHLAVEK (203 Czech Republic), Filip MALEK (203 Czech Republic), Marián FELŠŐCI (703 Slovakia, belonging to the institution), Jiří KETTNER (203 Czech Republic), Petr OSTADAL (203 Czech Republic), Cestmir CIHALIK (203 Czech Republic), Jiří ŠPÁC (203 Czech Republic, belonging to the institution), Hikmet AL-HITI (203 Czech Republic), Marian FEDORCO (703 Slovakia), Richard FOJT (203 Czech Republic), Andreas KRUGER (203 Czech Republic), Josef MALEK (203 Czech Republic), Tereza MIKUŠOVÁ (203 Czech Republic, belonging to the institution), Zdenek MONHART (203 Czech Republic), Stanislava BOHACOVA (203 Czech Republic), Lidka POHLUDKOVA (203 Czech Republic), Filip ROHAC (203 Czech Republic), Jan VACLAVIK (203 Czech Republic), Dagmar VONDRAKOVA (203 Czech Republic), Klaudia VYSKOČILOVÁ (703 Slovakia, belonging to the institution), Miroslav BAMBUCH (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

Plos one, San Francisco, Public Library of Science, 2015, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.057

RIV identification code

RIV/00216224:14110/15:00085555

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0117142

UT WoS

000350683900023

Keywords in English

BODY-MASS INDEX; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; OBESITY PARADOX; RISK-FACTORS; MORTALITY; ASSOCIATION; REGISTRY; ADIPOCYTOKINE; GUIDELINES

Abstract

V originále

Background Obesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking. Methods Using the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m(2) were excluded. All cause mortality was compared between groups with a BMI of 18.5-25 kg/m(2) and with BMI >25 kg/m(2). Data were adjusted by a propensity score for 11 parameters. Results In the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure. Conclusion These data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.

Links

MUNI/A/1012/2013, interní kód MU

Name: Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi

Investor: Masaryk University, Category A

Citovat

LITTNEROVÁ, Simona, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Ales LINHART, Petr WIDIMSKÝ, Jiří JARKOVSKÝ, Roman MIKLÍK, Lenka ŠPINAROVÁ, Kamil ZEMAN, Jan BELOHLAVEK, Filip MALEK, Marián FELŠŐCI, Jiří KETTNER, Petr OSTADAL, Cestmir CIHALIK, Jiří ŠPÁC, Hikmet AL-HITI, Marian FEDORCO, Richard FOJT, Andreas KRUGER, Josef MALEK, Tereza MIKUŠOVÁ, Zdenek MONHART, Stanislava BOHACOVA, Lidka POHLUDKOVA, Filip ROHAC, Jan VACLAVIK, Dagmar VONDRAKOVA, Klaudia VYSKOČILOVÁ, Miroslav BAMBUCH and Ladislav DUŠEK. Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure. Plos one. San Francisco: Public Library of Science, 2015, vol. 10, No 2, p. "e0117142", 15 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0117142.

@article{1322847,
   author = {Littnerová, Simona and Pařenica, Jiří and Špinar, Jindřich and Vítovec, Jiří and Linhart, Ales and Widimský, Petr and Jarkovský, Jiří and Miklík, Roman and Špinarová, Lenka and Zeman, Kamil and Belohlavek, Jan and Malek, Filip and Felšőci, Marián and Kettner, Jiří and Ostadal, Petr and Cihalik, Cestmir and Špác, Jiří and AlandHiti, Hikmet and Fedorco, Marian and Fojt, Richard and Kruger, Andreas and Malek, Josef and Mikušová, Tereza and Monhart, Zdenek and Bohacova, Stanislava and Pohludkova, Lidka and Rohac, Filip and Vaclavik, Jan and Vondrakova, Dagmar and Vyskočilová, Klaudia and Bambuch, Miroslav and Dušek, Ladislav},
   article_location = {San Francisco},
   article_number = {2},
   doi = {http://dx.doi.org/10.1371/journal.pone.0117142},
   keywords = {BODY-MASS INDEX; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; OBESITY PARADOX; RISK-FACTORS; MORTALITY; ASSOCIATION; REGISTRY; ADIPOCYTOKINE; GUIDELINES},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1322847
AU  - Littnerová, Simona - Pařenica, Jiří - Špinar, Jindřich - Vítovec, Jiří - Linhart, Ales - Widimský, Petr - Jarkovský, Jiří - Miklík, Roman - Špinarová, Lenka - Zeman, Kamil - Belohlavek, Jan - Malek, Filip - Felšőci, Marián - Kettner, Jiří - Ostadal, Petr - Cihalik, Cestmir - Špác, Jiří - Al-Hiti, Hikmet - Fedorco, Marian - Fojt, Richard - Kruger, Andreas - Malek, Josef - Mikušová, Tereza - Monhart, Zdenek - Bohacova, Stanislava - Pohludkova, Lidka - Rohac, Filip - Vaclavik, Jan - Vondrakova, Dagmar - Vyskočilová, Klaudia - Bambuch, Miroslav - Dušek, Ladislav
PY  - 2015
TI  - Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure
JF  - Plos one
VL  - 10
IS  - 2
SP  - "e0117142"
EP  - "e0117142"
PB  - Public Library of Science
SN  - 19326203
KW  - BODY-MASS INDEX
KW  - ACUTE MYOCARDIAL-INFARCTION
KW  - ACUTE CORONARY SYNDROMES
KW  - OBESITY PARADOX
KW  - RISK-FACTORS
KW  - MORTALITY
KW  - ASSOCIATION
KW  - REGISTRY
KW  - ADIPOCYTOKINE
KW  - GUIDELINES
N2  - Background Obesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking. Methods Using the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m(2) were excluded. All cause mortality was compared between groups with a BMI of 18.5-25 kg/m(2) and with BMI >25 kg/m(2). Data were adjusted by a propensity score for 11 parameters. Results In the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure. Conclusion These data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.
ER  -

LITTNEROVÁ, Simona, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Ales LINHART, Petr WIDIMSKÝ, Jiří JARKOVSKÝ, Roman MIKLÍK, Lenka ŠPINAROVÁ, Kamil ZEMAN, Jan BELOHLAVEK, Filip MALEK, Marián FELŠ$\backslash$H OCI, Jiří KETTNER, Petr OSTADAL, Cestmir CIHALIK, Jiří ŠPÁC, Hikmet AL-HITI, Marian FEDORCO, Richard FOJT, Andreas KRUGER, Josef MALEK, Tereza MIKUŠOVÁ, Zdenek MONHART, Stanislava BOHACOVA, Lidka POHLUDKOVA, Filip ROHAC, Jan VACLAVIK, Dagmar VONDRAKOVA, Klaudia VYSKOČILOVÁ, Miroslav BAMBUCH and Ladislav DUŠEK. Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure. \textit{Plos one}. San Francisco: Public Library of Science, 2015, vol.~10, No~2, p.~''e0117142'', 15 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0117142.

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