2016
ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children
BOŘILOVÁ LINHARTOVÁ, Petra; Jakub KAŠTOVSKÝ; Michaela BARTOŠOVÁ; Kristína MUSILOVÁ; Lenka ŽÁČKOVÁ et al.Základní údaje
Originální název
ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children
Název česky
ASOCIACE I/D ACE POLYMORFIZMU SE ZUBNÍM KAZEM VE STÁLÉ, ALE NE DOČASNÉ DENTICI U ČESKÝCH DĚTÍ
Autoři
BOŘILOVÁ LINHARTOVÁ, Petra; Jakub KAŠTOVSKÝ; Michaela BARTOŠOVÁ; Kristína MUSILOVÁ; Lenka ŽÁČKOVÁ; Martina KUKLETOVÁ; Lubomír KUKLA a Lydie IZAKOVIČOVÁ HOLLÁ
Vydání
Caries Research, Basel, Karger, 2016, 0008-6568
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.811
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/16:00087758
Organizační jednotka
Lékařská fakulta
UT WoS
EID Scopus
Klíčová slova česky
genový polymorfizmus; ACE; zubní kaz; děti; ELSPAC
Klíčová slova anglicky
gene polymorphism; ACE; dental caries; children; ELSPAC
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 2. 8. 2016 13:47, Ing. Mgr. Věra Pospíšilíková
V originále
Objective: Dental caries is a multifactorial, infectious disease where genetic predisposition plays an important role. Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) has very recently been associated with caries in Polish children. The aim of this study was to analyze ACE I/D polymorphism in a group of caries-free children versus subjects affected by dental caries in the Czech population. Materials and Methods: In this case-control study, 182 caries-free children (with decayed/missing/filled teeth, DMFT = 0), 561 subjects with dental caries (DMFT 1) aged 13–15 years and 220 children aged 2–6 years with early childhood caries (ECC, dmft 1) were included. Genotype determination of ACE I/D polymorphism in intron 16 was based on the TaqMan method. Results: Although no significant differences in the allele or genotype frequencies between the cariesfree children and those affected by dental caries were observed, statistically significant differences between the children with DMFT = 0 and the subgroup of 179 patients with high caries experience (DMFT 4; p < 0.01 and p < 0.05, respectively) were detected. The comparison of DD versus II+ID genotype frequencies between the patients with DMFT 1 or DMFT 4 and healthy children also showed significant differences (31.5% or 35.6% vs. 23.6%, p < 0.05 or p < 0.01, respectively). A gender-based analysis identified a significant difference in the DD versus II+ID genotype frequencies only in girls (p < 0.05). In contrast, no significant association of ACE I/D polymorphism with ECC in young children was found (p > 0.05). Conclusions: ACE I/D polymorphism may be associated with caries in permanent but not primary dentition, especially in girls in the Czech population.
Česky
Cílem studie bylo analyzovat ACE I/D polymorfizmus ve skupině dětí bez zubního kazu vs. u dětí s kazem v české populaci.
Návaznosti
| GB14-37368G, projekt VaV |
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| MUNI/A/1359/2014, interní kód MU |
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| MUNI/M/1075/2013, interní kód MU |
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| NT11405, projekt VaV |
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