Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of
serine peptidases

k 2016

Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases

ROUDNICKÝ, Pavel; Jiří VOREL; Jana ILGOVÁ; Libor MIKEŠ; Lucie JEDLIČKOVÁ et al.

Základní údaje

Originální název

Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases

Název česky

Eudiplozoon nipponicum (Monogenea): serpiny - inhibitory serinových peptidáz

Autoři

ROUDNICKÝ, Pavel; Jiří VOREL; Jana ILGOVÁ; Libor MIKEŠ; Lucie JEDLIČKOVÁ; Jan DVOŘÁK; Milan GELNAR a Martin KAŠNÝ

Vydání

České a slovenské parazitologické dny 2016, 2016

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/16:00087986

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

eudiplozoon; serpin; peptidáza; inhibitor; parazit; funkční molekula

Klíčová slova anglicky

eudiplozoon; serpin; peptidase; inhibitor; parasite; functional molecule

Změněno: 25. 3. 2017 07:39, RNDr. Martin Kašný, Ph.D.

Anotace

V originále

Eudiplozoon nipponicum is a platyhelminth, from the class Monogenea, family Diplozoidae. It is oviparous, hematophagous ectoparasite of common carp (Cyprinus carpio). Proteolytic enzymes (peptidases) are functional molecules, which catabolize cleavage of peptide bonds of proteins. According to the process of their action they are divided into several groups (e.g. cysteine, serine, aspartic, metallo- peptidases). Serine peptidases are known as a key factors of many physiological processes of higher organisms, such as complement cascade activation, blood clotting, fibrinolysis, inflammation and programmed apoptosis. Parasites employ the serine peptidases e.g. during invasion and migration of the host tissue and digestion. For each living organisms, the regulation of the activity of peptidases represents the crucial step and it can be mediated also by natural inhibitors, such as serpins – the inhibitors of serine peptidases. In transcriptomes/genomes of various helminth species, we can find high number of genes, coding serpins. In transcriptomic data, obtained on our experimental organism E. nipponicum we identified several sequences corresponding to serpins. Up to now no monogenean serpin has been characterized. The results of our preliminary experiments realized with recombinant serpin protein molecule indicates that function of the serpins could be similar to other blood feeding worms. This means, that eudiplozoon probably adopted similar mechanisms enabling to avoid inflammation, activation of complement and blood clotting.

Návaznosti

GBP505/12/G112, projekt VaV

Název: ECIP - Evropské centrum ichtyoparazitologie

Investor: Grantová agentura ČR, ECIP - Evropské centrum ichtyoparazitologie

MUNI/A/1325/2015, interní kód MU

Název: Analýzy diverzity biologických systémů různých úrovní a na různých škálách prostředí (Akronym: BIDA5)

Investor: Masarykova univerzita, Analýzy diverzity biologických systémů různých úrovní a na různých škálách prostředí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ROUDNICKÝ, Pavel; Jiří VOREL; Jana ILGOVÁ; Libor MIKEŠ; Lucie JEDLIČKOVÁ; Jan DVOŘÁK; Milan GELNAR a Martin KAŠNÝ. Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases. In České a slovenské parazitologické dny 2016. 2016.

@proceedings{1347756,
   author = {Roudnický, Pavel and Vorel, Jiří and Ilgová, Jana and Mikeš, Libor and Jedličková, Lucie and Dvořák, Jan and Gelnar, Milan and Kašný, Martin},
   booktitle = {České a slovenské parazitologické dny 2016},
   keywords = {eudiplozoon; serpin; peptidase; inhibitor; parasite; functional molecule},
   language = {eng},
   title = {Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases},
   year = {2016}
}

TY  - CONF
ID  - 1347756
AU  - Roudnický, Pavel - Vorel, Jiří - Ilgová, Jana - Mikeš, Libor - Jedličková, Lucie - Dvořák, Jan - Gelnar, Milan - Kašný, Martin
PY  - 2016
TI  - Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases
KW  - eudiplozoon
KW  - serpin
KW  - peptidase
KW  - inhibitor
KW  - parasite
KW  - functional molecule
N2  - Eudiplozoon nipponicum is a platyhelminth, from the class Monogenea, family Diplozoidae. It is oviparous, hematophagous ectoparasite of common carp (Cyprinus carpio). Proteolytic enzymes (peptidases) are functional molecules, which catabolize cleavage of peptide bonds of proteins. According to the process of their action they are divided into several groups (e.g. cysteine, serine, aspartic, metallo- peptidases). Serine peptidases are known as a key factors of many physiological processes of higher organisms, such as complement cascade activation, blood clotting, fibrinolysis, inflammation and programmed apoptosis. Parasites employ the serine peptidases e.g. during invasion and migration of the host tissue and digestion. For each living organisms, the regulation of the activity of peptidases represents the crucial step and it can be mediated also by natural inhibitors, such as serpins – the inhibitors of serine peptidases. In transcriptomes/genomes of various helminth species, we can find high number of genes, coding serpins. In transcriptomic data, obtained on our experimental organism E. nipponicum we identified several sequences corresponding to serpins. Up to now no monogenean serpin has been characterized. The results of our preliminary experiments realized with recombinant serpin protein molecule indicates that function of the serpins could be similar to other blood feeding worms. This means, that eudiplozoon probably adopted similar mechanisms enabling to avoid inflammation, activation of complement and blood clotting.
ER  -

ROUDNICKÝ, Pavel; Jiří VOREL; Jana ILGOVÁ; Libor MIKEŠ; Lucie JEDLIČKOVÁ; Jan DVOŘÁK; Milan GELNAR a Martin KAŠNÝ. Eudiplozoon nipponicum (Monogenea): serpins – inhibitors of serine peptidases. In \textit{České a slovenské parazitologické dny 2016}. 2016.

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