| SPANIEL, Filip, Jaroslav TINTERA, Jan RYDLO, Ibrahim IBRAHIM, Tomáš KAŠPÁREK, Jiri HORACEK, Natalie ZAYTSEVA, Martin MATEJKA, Marketa FIALOVA, Andrea SLOVAKOVA, Pavol MIKOLAS, Tomas MELICHER, Natalie GÖRNEROVA, Cyril HÖSCHL a Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, roč. 42, č. 4, s. 916-925. ISSN 0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbv188. |
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@article{1349625,
author = {Spaniel, Filip and Tintera, Jaroslav and Rydlo, Jan and Ibrahim, Ibrahim and Kašpárek, Tomáš and Horacek, Jiri and Zaytseva, Natalie and Matejka, Martin and Fialova, Marketa and Slovakova, Andrea and Mikolas, Pavol and Melicher, Tomas and Görnerova, Natalie and Höschl, Cyril and Hajek, Tomas},
article_location = {Oxford},
article_number = {4},
doi = {http://dx.doi.org/10.1093/schbul/sbv188},
keywords = {first-episode schizophrenia; neuroimaging; fMRI; self-agency; independent component analysis},
language = {eng},
issn = {0586-7614},
journal = {Schizophrenia Bulletin},
title = {Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study},
volume = {42},
year = {2016}
}
TY - JOUR
ID - 1349625
AU - Spaniel, Filip - Tintera, Jaroslav - Rydlo, Jan - Ibrahim, Ibrahim - Kašpárek, Tomáš - Horacek, Jiri - Zaytseva, Natalie - Matejka, Martin - Fialova, Marketa - Slovakova, Andrea - Mikolas, Pavol - Melicher, Tomas - Görnerova, Natalie - Höschl, Cyril - Hajek, Tomas
PY - 2016
TI - Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study
JF - Schizophrenia Bulletin
VL - 42
IS - 4
SP - 916-925
EP - 916-925
PB - Oxford University Press
SN - 05867614
KW - first-episode schizophrenia
KW - neuroimaging
KW - fMRI
KW - self-agency
KW - independent component analysis
N2 - Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
ER -
SPANIEL, Filip, Jaroslav TINTERA, Jan RYDLO, Ibrahim IBRAHIM, Tomáš KAŠPÁREK, Jiri HORACEK, Natalie ZAYTSEVA, Martin MATEJKA, Marketa FIALOVA, Andrea SLOVAKOVA, Pavol MIKOLAS, Tomas MELICHER, Natalie GÖRNEROVA, Cyril HÖSCHL a Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, roč.~42, č.~4, s.~916-925. ISSN~0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbv188.
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