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@article{1352749,
author = {Šponerová, Judit and Šponer, Jiří and Nováková, Olga and Brabec, Viktor and Šedo, Ondrej and Zdráhal, Zbyněk and Costanzo, Giovanna and Pino, Samanta and Saladino, Raffaele and Di Mauro, Ernesto},
article_location = {WEINHEIM},
article_number = {11},
doi = {http://dx.doi.org/10.1002/chem.201503906},
keywords = {formamide; nucleobases; nucleotides; origin of life; RNA},
language = {eng},
issn = {0947-6539},
journal = {Chemistry - A European Journal},
title = {Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario},
url = {http://onlinelibrary.wiley.com/doi/10.1002/chem.201503906/full},
volume = {22},
year = {2016}
}
TY - JOUR
ID - 1352749
AU - Šponerová, Judit - Šponer, Jiří - Nováková, Olga - Brabec, Viktor - Šedo, Ondrej - Zdráhal, Zbyněk - Costanzo, Giovanna - Pino, Samanta - Saladino, Raffaele - Di Mauro, Ernesto
PY - 2016
TI - Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario
JF - Chemistry - A European Journal
VL - 22
IS - 11
SP - 3572-3586
EP - 3572-3586
PB - Wiley
SN - 09476539
KW - formamide
KW - nucleobases
KW - nucleotides
KW - origin of life
KW - RNA
UR - http://onlinelibrary.wiley.com/doi/10.1002/chem.201503906/full
L2 - http://onlinelibrary.wiley.com/doi/10.1002/chem.201503906/full
N2 - 50years after the historical Miller-Urey experiment, the formamide-based scenario is perhaps the most powerful concurrent hypothesis for the origin of life on our planet besides the traditional HCN-based concept. The information accumulated during the last 15years in this topic is astonishingly growing and nowadays the formamide-based model represents one of the most complete and coherent pathways leading from simple prebiotic precursors up to the first catalytically active RNA molecules. In this work, we overview the major events of this long pathway that have emerged from recent experimental and theoretical studies, mainly concentrating on the mechanistic, methodological, and structural aspects of this research.
ER -
ŠPONEROVÁ, Judit, Jiří ŠPONER, Olga NOVÁKOVÁ, Viktor BRABEC, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Giovanna COSTANZO, Samanta PINO, Raffaele SALADINO a Ernesto DI MAURO. Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario. \textit{Chemistry - A European Journal}. WEINHEIM: Wiley, roč.~22, č.~11, s.~3572-3586. ISSN~0947-6539. doi:10.1002/chem.201503906. 2016.
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