Polymorphisms in genes encoding purinoreceptor and
osteoprotegerin and external apical root resorption in children
after orthodontic treatment

k 2016

Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment

VRANKOVÁ, Zuzana, Martina SIROTKOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Pavlína ČERNOCHOVÁ, Jakub KAŠTOVSKÝ et. al.

Základní údaje

Originální název

Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment

Autoři

VRANKOVÁ, Zuzana (703 Slovensko, domácí), Martina SIROTKOVÁ (703 Slovensko, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, garant, domácí), Pavlína ČERNOCHOVÁ (203 Česká republika, domácí), Jakub KAŠTOVSKÝ (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí)

Vydání

15th Euro Congress on Dental & Oral Health, Rome, 2016

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

Genetika a molekulární biologie

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/16:00088272

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4172/2161-1122.C1.006

Klíčová slova anglicky

polymorphism; purinoreceptor; osteoprotegerin; external apical root resorption; orthodontic treatment

Štítky

EL OK

Změněno: 20. 12. 2016 13:28, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Orthodontically induced external apical root resoption (EARR) is a multifactorial inflammatory disease. Genes encoding proteins, which are involved in the modulation of inflammatory response and bone remodeling, are considered as the “candidate” for EARR. The aim of this study was to analyze possible associations of single nucleotide polymorphisms (SNPs) in the P2RX7 (encoding purinoreceptor) and TNFRSF11B (encoding osteoprotegerin) genes with EARR in Czech children after orthodontic treatment. A total, 99 orthodontically treated patients (69 healthy and 30 with EARR) were enrolled in this case-control study. Genotype determination of P2RX7 +489C/T (rs208294, Tyr155His) and +1068C/T (rs1718119, Thr348Ala), TNFRSF11B -163C/T (rs3102735) and TNFRSF11B +1181C/G (rs2073618, Lys3Asn) was based on polymerase chain reaction using 5 nuclease TaqMan® assays. While no significant differences were observed in allele or genotype frequencies of all four studied SNPs, specific combinations of variants in P2RX7 may be associated with lower/higher risk of EARR development (P<0.05). In addition, the length of treatment by orthodontic appliances positively correlated with the presence of EARR (P<0.05). Although the effect of P2RX7 SNPs themselves to the development EARR was not confirmed in the Czech population, haplotype analysis suggests, that variability in the P2RX7 gene, as well as the length of treatment, may be important factors contributing to the etiopathogenesis of post-orthodontic EARR.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1258/2015, interní kód MU

Název: Analýza klinických, mikrobiálních a genetických faktorů v etiopatogenezi vybraných patologických stavů v dutině ústní

Investor: Masarykova univerzita, Analýza klinických, mikrobiálních a genetických faktorů v etiopatogenezi vybraných patologických stavů v dutině ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

VRANKOVÁ, Zuzana, Martina SIROTKOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Pavlína ČERNOCHOVÁ, Jakub KAŠTOVSKÝ a Lydie IZAKOVIČOVÁ HOLLÁ. Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment. In 15th Euro Congress on Dental & Oral Health, Rome. 2016. Dostupné z: https://dx.doi.org/10.4172/2161-1122.C1.006.

@proceedings{1358135,
   author = {Vranková, Zuzana and Sirotková, Martina and Bořilová Linhartová, Petra and Černochová, Pavlína and Kaštovský, Jakub and Izakovičová Hollá, Lydie},
   booktitle = {15th Euro Congress on Dental & Oral Health, Rome},
   doi = {http://dx.doi.org/10.4172/2161-1122.C1.006},
   keywords = {polymorphism; purinoreceptor; osteoprotegerin; external apical root resorption; orthodontic treatment},
   language = {eng},
   title = {Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment},
   year = {2016}
}

TY  - CONF
ID  - 1358135
AU  - Vranková, Zuzana - Sirotková, Martina - Bořilová Linhartová, Petra - Černochová, Pavlína - Kaštovský, Jakub - Izakovičová Hollá, Lydie
PY  - 2016
TI  - Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
KW  - polymorphism
KW  - purinoreceptor
KW  - osteoprotegerin
KW  - external apical root resorption
KW  - orthodontic treatment
N2  - Orthodontically induced external apical root resoption (EARR) is a multifactorial inflammatory disease. Genes encoding proteins, which are involved in the modulation of inflammatory response and bone remodeling, are considered as the “candidate” for EARR. The aim of this study was to analyze possible associations of single nucleotide polymorphisms (SNPs) in the P2RX7 (encoding purinoreceptor) and TNFRSF11B (encoding osteoprotegerin) genes with EARR in Czech children after orthodontic treatment. A total, 99 orthodontically treated patients (69 healthy and 30 with EARR) were enrolled in this case-control study. Genotype determination of P2RX7 +489C/T (rs208294, Tyr155His) and +1068C/T (rs1718119, Thr348Ala), TNFRSF11B -163C/T (rs3102735) and TNFRSF11B +1181C/G (rs2073618, Lys3Asn) was based on polymerase chain reaction using 5 nuclease TaqMan® assays. While no significant differences were observed in allele or genotype frequencies of all four studied SNPs, specific combinations of variants in P2RX7 may be associated with lower/higher risk of EARR development (P<0.05). In addition, the length of treatment by orthodontic appliances positively correlated with the presence of EARR (P<0.05). Although the effect of P2RX7 SNPs themselves to the development EARR was not confirmed in the Czech population, haplotype analysis suggests, that variability in the P2RX7 gene, as well as the length of treatment, may be important factors contributing to the etiopathogenesis of post-orthodontic EARR.
ER  -

VRANKOVÁ, Zuzana, Martina SIROTKOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Pavlína ČERNOCHOVÁ, Jakub KAŠTOVSKÝ a Lydie IZAKOVIČOVÁ HOLLÁ. Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment. In \textit{15th Euro Congress on Dental \&{} Oral Health, Rome}. 2016. Dostupné z: https://dx.doi.org/10.4172/2161-1122.C1.006.

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