Malignant catatonia due to anti-NMDA-receptor encephalitis in a
15-year-old girl: case report and summary of current knowledge

J 2016

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

AULICKÁ, Štefánia; Ondřej HORÁK; Lenka MRÁZOVÁ; Peter MIKOLÁŠEK; Jaroslav ŠTĚRBA et. al.

Základní údaje

Originální název

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

Autoři

AULICKÁ, Štefánia; Ondřej HORÁK; Lenka MRÁZOVÁ; Peter MIKOLÁŠEK; Jaroslav ŠTĚRBA; Lenka KRBKOVÁ a Hana OŠLEJŠKOVÁ

Vydání

Neuropsychiatry, London, Future Medicine Ltd. 2016, 1758-2008

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.778

Kód RIV

RIV/00216224:14110/16:00091888

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4172/Neuropsychiatry.1000132

EID Scopus

2-s2.0-85018520181

Klíčová slova anglicky

NMDA receptor antibodies; malignant catatonia; paraneoplastic form; non-paraneoplastic form; immunotherapy

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 7. 2025 11:56, Mgr. Petra Trembecká, Ph.D.

Anotace

V originále

Anti-N-methyl-D-aspartate receptor encephalitis is a recently identified autoimmune disorder with a prominent neuropsychiatric presentation. We present the case of a 15-yearold girl with partial complex seizures with secondary generalization and acute mania with psychotic features. A positive diagnosis of anti-NMDA-receptor encephalitis suggested the specific treatment. Despite first-line immune treatment, the patient progressed to stupor, malignant catatonia, and autonomic instability with the risk of cardiopulmonary function failure. She improved after second-line immunosuppressive therapy (cyclophosphamide and rituximab simultaneously). Post-cognitive sequelae (memory impairment and deliberation) disappeared within 8 months of follow-up treatment and intensive cognitive rehabilitation. This case report emphasizes the importance of differential diagnosis and adequate treatment of catatonic syndrome, especially in young adults. Early recognition and adequate treatment is essential for a good outcome for the patients.

Návaznosti

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

AULICKÁ, Štefánia; Ondřej HORÁK; Lenka MRÁZOVÁ; Peter MIKOLÁŠEK; Jaroslav ŠTĚRBA; Lenka KRBKOVÁ a Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. Neuropsychiatry. London: Future Medicine Ltd., 2016, roč. 6, č. 4, s. 136-141. ISSN 1758-2008. Dostupné z: https://doi.org/10.4172/Neuropsychiatry.1000132.

@article{1361661,
   author = {Aulická, Štefánia and Horák, Ondřej and Mrázová, Lenka and Mikolášek, Peter and Štěrba, Jaroslav and Krbková, Lenka and Ošlejšková, Hana},
   article_location = {London},
   article_number = {4},
   doi = {https://doi.org/10.4172/Neuropsychiatry.1000132},
   keywords = {NMDA receptor antibodies; malignant catatonia; paraneoplastic form; non-paraneoplastic form; immunotherapy},
   language = {eng},
   issn = {1758-2008},
   journal = {Neuropsychiatry},
   title = {Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge},
   url = {https://www.openaccessjournals.com/peer-review/malignant-catatonia-due-to-antinmdareceptor-encephalitis-in-a-15yearold-girl-case-report-and-summary-of-current-knowledge.html},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1361661
AU  - Aulická, Štefánia - Horák, Ondřej - Mrázová, Lenka - Mikolášek, Peter - Štěrba, Jaroslav - Krbková, Lenka - Ošlejšková, Hana
PY  - 2016
TI  - Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge
JF  - Neuropsychiatry
VL  - 6
IS  - 4
SP  - 136-141
EP  - 136-141
PB  - Future Medicine Ltd.
SN  - 17582008
KW  - NMDA receptor antibodies
KW  - malignant catatonia
KW  - paraneoplastic form
KW  - non-paraneoplastic form
KW  - immunotherapy
UR  - https://www.openaccessjournals.com/peer-review/malignant-catatonia-due-to-antinmdareceptor-encephalitis-in-a-15yearold-girl-case-report-and-summary-of-current-knowledge.html
N2  - Anti-N-methyl-D-aspartate receptor encephalitis is a recently identified autoimmune disorder with a prominent neuropsychiatric presentation. We present the case of a 15-yearold girl with partial complex seizures with secondary generalization and acute mania with psychotic features. A positive diagnosis of anti-NMDA-receptor encephalitis suggested the specific treatment. Despite first-line immune treatment, the patient progressed to stupor, malignant catatonia, and autonomic instability with the risk of cardiopulmonary function failure. She improved after second-line immunosuppressive therapy (cyclophosphamide and rituximab simultaneously). Post-cognitive sequelae (memory impairment and deliberation) disappeared within 8 months of follow-up treatment and intensive cognitive rehabilitation. This case report emphasizes the importance of differential diagnosis and adequate treatment of catatonic syndrome, especially in young adults. Early recognition and adequate treatment is essential for a good outcome for the patients.
ER  -

AULICKÁ, Štefánia; Ondřej HORÁK; Lenka MRÁZOVÁ; Peter MIKOLÁŠEK; Jaroslav ŠTĚRBA; Lenka KRBKOVÁ a Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. \textit{Neuropsychiatry}. London: Future Medicine Ltd., 2016, roč.~6, č.~4, s.~136-141. ISSN~1758-2008. Dostupné z: https://doi.org/10.4172/Neuropsychiatry.1000132.

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