2016
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
ŠTOURAČ, PetrZákladní údaje
Originální název
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Název česky
Remifentanil v reálných klinických podmínkách: Podivuhodný příběh dr. Jekylla a Mr. Hydea?
Název anglicky
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Autoři
Vydání
Current medical research and opinion, Oxon, Taylor & Francis, 2016, 0300-7995
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.757
Označené pro přenos do RIV
Ne
Organizační jednotka
Lékařská fakulta
UT WoS
Klíčová slova česky
remifentanil; porodní analgezie: opioidy navozená hyperalgezie
Klíčová slova anglicky
remifentnail; obstetric analgesia; opioid-induced hyperalgesia
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 27. 1. 2017 09:59, Ing. Mgr. Věra Pospíšilíková
V originále
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.
Anglicky
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.