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@article{1361920,
author = {Marečková, Klára and Holsen, Laura M. and Admon, Roee and Makris, Nikos and Seidman, Larry and Buka, Stephen and WhitfieldandGabrieli, Susan and Goldstein, Jill M.},
article_location = {Hoboken},
article_number = {11},
doi = {http://dx.doi.org/10.1002/hbm.23271},
keywords = {dysphoric mood state; sex; functional magnetic resonance imaging; generalized psychophysiological interaction; negative affect; International Affective Picture System; Research Domain Criteria},
language = {eng},
issn = {1065-9471},
journal = {Human Brain mapping},
title = {Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses},
url = {http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf},
volume = {37},
year = {2016}
}
TY - JOUR
ID - 1361920
AU - Marečková, Klára - Holsen, Laura M. - Admon, Roee - Makris, Nikos - Seidman, Larry - Buka, Stephen - Whitfield-Gabrieli, Susan - Goldstein, Jill M.
PY - 2016
TI - Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses
JF - Human Brain mapping
VL - 37
IS - 11
SP - 3733-3744
EP - 3733-3744
PB - WILEY-BLACKWELL
SN - 10659471
KW - dysphoric mood state
KW - sex
KW - functional magnetic resonance imaging
KW - generalized psychophysiological interaction
KW - negative affect
KW - International Affective Picture System
KW - Research Domain Criteria
UR - http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf
L2 - http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf
N2 - Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to negative valence/high arousal and neutral valence/low arousal images as a function of dysphoric mood and sex across individuals (n=99) who represented traditional categories of healthy controls, major depressive disorder, bipolar psychosis, and schizophrenia. Observation of negative (vs. neutral) stimuli elicited blood oxygen-level dependent responses in the following circuitry: periaqueductal gray, hypothalamus (HYPO), amygdala (AMYG), hippocampus (HIPP), orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), and greater connectivity between AMYG and mPFC. Across all subjects, severity of dysphoric mood was associated with hyperactivity of HYPO, and, among females, right (R) AMYG. Females also demonstrated inverse relationships between severity of dysphoric mood and connectivity between HYPO - R OFC, R AMYG - R OFC, and R AMYG - R HIPP. Overall, our findings demonstrated sex-dependent deficits in response to negative affective stimuli increasing as a function of dysphoric mood state. Females demonstrated greater inability to regulate arousal as mood became more dysphoric. These findings contribute to elucidating biosignatures associated with response to negative stimuli across disorders and suggest the importance of a sex-dependent lens in determining these biosignatures. Hum Brain Mapp 37:3733-3744, 2016. (c) 2016 Wiley Periodicals, Inc.
ER -
MAREČKOVÁ, Klára, Laura M. HOLSEN, Roee ADMON, Nikos MAKRIS, Larry SEIDMAN, Stephen BUKA, Susan WHITFIELD-GABRIELI and Jill M. GOLDSTEIN. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. \textit{Human Brain mapping}. Hoboken: WILEY-BLACKWELL, 2016, vol.~37, No~11, p.~3733-3744. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.23271.
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