J 2016

Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus

VOLEJNIKOVA, Jana, Viera BAJČIOVÁ, Lucie SULOVSKA, Marie GEIEROVA, Eva BURIANKOVA et. al.

Základní údaje

Originální název

Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus

Název anglicky

Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus

Autoři

VOLEJNIKOVA, Jana (203 Česká republika), Viera BAJČIOVÁ (703 Slovensko, domácí), Lucie SULOVSKA (203 Česká republika), Marie GEIEROVA (203 Česká republika), Eva BURIANKOVA (203 Česká republika), Marie JAROSOVA (203 Česká republika), Marian HAJDUCH (203 Česká republika), Jaroslav ŠTĚRBA (203 Česká republika, garant, domácí) a Vladimir MIHAL (203 Česká republika)

Vydání

Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Palacký University, 2016, 1213-8118

Další údaje

Jazyk

čeština

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.894

Kód RIV

RIV/00216224:14110/16:00092091

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000392808100019

Klíčová slova anglicky

Bone marrow; Childhood; Congenital melanocytic nevus; Malignant melanoma; Metastasis

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 4. 4. 2017 13:25, Soňa Böhmová

Anotace

ORIG EN

V originále

Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.

Anglicky

Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.