| USTOHAL, Libor, Michaela MAYEROVÁ, Veronika HUBLOVÁ, Hana PŘIKRYLOVÁ KUČEROVÁ, Eva ČEŠKOVÁ a Tomáš KAŠPÁREK. Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study. Journal of Psychopharmacology. London, UK: SAGE Publications, 2017, roč. 31, č. 4, s. 500-504. ISSN 0269-8811. doi:10.1177/0269881116662650. |
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@article{1381935,
author = {Ustohal, Libor and Mayerová, Michaela and Hublová, Veronika and Přikrylová Kučerová, Hana and Češková, Eva and Kašpárek, Tomáš},
article_location = {London, UK},
article_number = {4},
doi = {http://dx.doi.org/10.1177/0269881116662650},
keywords = {Schizophrenia; cortical inhibition; cortical silent period; risperidone; transcranial magnetic stimulation},
language = {eng},
issn = {0269-8811},
journal = {Journal of Psychopharmacology},
title = {Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study},
url = {http://journals.sagepub.com/doi/10.1177/0269881116662650},
volume = {31},
year = {2017}
}
TY - JOUR
ID - 1381935
AU - Ustohal, Libor - Mayerová, Michaela - Hublová, Veronika - Přikrylová Kučerová, Hana - Češková, Eva - Kašpárek, Tomáš
PY - 2017
TI - Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study
JF - Journal of Psychopharmacology
VL - 31
IS - 4
SP - 500-504
EP - 500-504
PB - SAGE Publications
SN - 02698811
KW - Schizophrenia
KW - cortical inhibition
KW - cortical silent period
KW - risperidone
KW - transcranial magnetic stimulation
UR - http://journals.sagepub.com/doi/10.1177/0269881116662650
L2 - http://journals.sagepub.com/doi/10.1177/0269881116662650
N2 - Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABA(B)) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.2041.81 ms to 162.95 +/- 61.98 ms (p=0.041; Cohen's d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores (p<0.05). However, no correlation was found between CSP and PANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABA(B) mediated inhibitory neurotransmission.
ER -
USTOHAL, Libor, Michaela MAYEROVÁ, Veronika HUBLOVÁ, Hana PŘIKRYLOVÁ KUČEROVÁ, Eva ČEŠKOVÁ a Tomáš KAŠPÁREK. Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study. \textit{Journal of Psychopharmacology}. London, UK: SAGE Publications, 2017, roč.~31, č.~4, s.~500-504. ISSN~0269-8811. doi:10.1177/0269881116662650.
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