Levels of heavy metals and their binding protein
metallothionein in type 2 diabetics with kidney disease

J 2017

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

RAUDENSKÁ, Martina; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Katarína CHALÁSOVÁ; Monika KRATOCHVÍLOVÁ et al.

Základní údaje

Originální název

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Autoři

Vydání

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, HOBOKEN, WILEY, 2017, 1095-6670

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.837

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00094919

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2018 11:10, Soňa Böhmová

Anotace

V originále

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Návaznosti

GA16-14829S, projekt VaV

Název: Efekt diabetického mikroprostředí na vybrané procesy při vzniku kolorektálního karcinomu, jeho klinický průběh a odpověď na terapii

Investor: Grantová agentura ČR, Efekt diabetického mikroprostředí na vybrané procesy při vzniku kolorektálního karcinomu, jeho klinický průběh a odpověď na terapii

Citovat

RAUDENSKÁ, Martina; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Katarína CHALÁSOVÁ; Monika KRATOCHVÍLOVÁ; Jaromír GUMULEC; B. RUTTKAY-NEDECKY; O. ZITKA; Kateřina KAŇKOVÁ; V. ADAM a Michal MASAŘÍK. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. HOBOKEN: WILEY, 2017, roč. 31, č. 6, s. 1-5. ISSN 1095-6670. Dostupné z: https://doi.org/10.1002/jbt.21891.

@article{1388756,
   author = {Raudenská, Martina and Dvořáková, Veronika and Pácal, Lukáš and Chalásová, Katarína and Kratochvílová, Monika and Gumulec, Jaromír and RuttkayandNedecky, B. and Zitka, O. and Kaňková, Kateřina and Adam, V. and Masařík, Michal},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {https://doi.org/10.1002/jbt.21891},
   keywords = {diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress},
   language = {eng},
   issn = {1095-6670},
   journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
   title = {Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1388756
AU  - Raudenská, Martina - Dvořáková, Veronika - Pácal, Lukáš - Chalásová, Katarína - Kratochvílová, Monika - Gumulec, Jaromír - Ruttkay-Nedecky, B. - Zitka, O. - Kaňková, Kateřina - Adam, V. - Masařík, Michal
PY  - 2017
TI  - Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease
JF  - JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
VL  - 31
IS  - 6
SP  - 1-5
EP  - 1-5
PB  - WILEY
SN  - 10956670
KW  - diabetes
KW  - diabetic kidney disease
KW  - heavy metals
KW  - metallothionein
KW  - oxidative stress
N2  - Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
ER  -

RAUDENSKÁ, Martina; Veronika DVOŘÁKOVÁ; Lukáš PÁCAL; Katarína CHALÁSOVÁ; Monika KRATOCHVÍLOVÁ; Jaromír GUMULEC; B. RUTTKAY-NEDECKY; O. ZITKA; Kateřina KAŇKOVÁ; V. ADAM a Michal MASAŘÍK. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. \textit{JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}. HOBOKEN: WILEY, 2017, roč.~31, č.~6, s.~1-5. ISSN~1095-6670. Dostupné z: https://doi.org/10.1002/jbt.21891.

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