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@proceedings{1395667,
author = {Masopustová, Lucie and Bořilová Linhartová, Petra and Slezáková, Simona and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie},
booktitle = {XVIII. Setkání biochemiků a molekulárních biologů, Brno},
keywords = {myeloperoxidase; association studies; candidate gene; genetic; immunity; oral ulcer; polymorphisms},
language = {eng},
isbn = {978-80-210-8765-1},
title = {Myeloperoxidase (MPO) gene variability in patients with recurrent aphthous stomatitis},
year = {2017}
}
TY - CONF
ID - 1395667
AU - Masopustová, Lucie - Bořilová Linhartová, Petra - Slezáková, Simona - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY - 2017
TI - Myeloperoxidase (MPO) gene variability in patients with recurrent aphthous stomatitis
SN - 9788021087651
KW - myeloperoxidase
KW - association studies
KW - candidate gene
KW - genetic
KW - immunity
KW - oral ulcer
KW - polymorphisms
N2 - Introduction: Recurrent aphthous stomatitis (RAS) is a multifactorial disease, the exact etiological factor(s) are not understood. One of the contributing factors is oxidative stress caused by an imbalance between reactive oxygen species (ROS) and an antioxidant system. Myeloperoxidase (MPO) is an enzyme utilizing the oxidation potential of superoxides and hydrogen peroxide to convert chloride ions to chlorine and another ROS. The aim of this study was to determine polymorphisms in MPO (rs2243828, rs2759, rs7208693, rs2333227) in RAS patients and control subjects in Czech population. Materials and methods: We performed a case–control study in 275 subjects (70 patients with recurrent aphthous stomatitis and 205 healthy individuals). Polymorphisms were detected by using real-time PCR with the use of TaqMan probe and RFLP-PCR with restriction analysis. Results: No statistically significant differences were found in allelic and genotypic frequencies of MPO polymorphisms (rs2243828, rs2759, rs7208693, rs2333227) among patients with RAS and controls. However statistical significance was found in SNP MPO (rs2333227, rs2243828) when comparing the duration of lesions, difference is between individuals with the GG genotype compared to carriers of AA + AG genotypes (P = 0.02). No significant association was detected between MPO haplotypes and RAS. Conclusion: When comparing our results with studies in the Turkish population, we concluded that variability in the myeloperoxidase gene may not play a role in the development of the disease. Acknowledgements: This study was supported by grant AZV 15-29336A, GAČR GB14-37368G and project MUNI / A / 0948/2016.
ER -
MASOPUSTOVÁ, Lucie, Petra BOŘILOVÁ LINHARTOVÁ, Simona SLEZÁKOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Myeloperoxidase (MPO) gene variability in patients with recurrent aphthous stomatitis. In \textit{XVIII. Setkání biochemiků a molekulárních biologů, Brno}. 2017. ISBN~978-80-210-8765-1.
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