Neural evidence for defective top-down control of visual
processing in Parkinson's and Alzheimer's disease

J 2017

Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease

NĚMCOVÁ ELFMARKOVÁ, Nela; Martin GAJDOŠ; Irena REKTOROVÁ; Radek MAREČEK; Steven Z. RAPCSAK et al.

Základní údaje

Originální název

Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease

Autoři

NĚMCOVÁ ELFMARKOVÁ, Nela; Martin GAJDOŠ ; Irena REKTOROVÁ; Radek MAREČEK a Steven Z. RAPCSAK

Vydání

Neuropsychologia, Oxford, Pergamon-Elsevier Science LTD, 2017, 0028-3932

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.889

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00098495

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Alzheimer's disease; fMRI; Mild cognitive impairment; Parkinson's disease; Top-down visual processing

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 17:01, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50% sensitivity and 86.98% specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

734718, interní kód MU

Název: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Akronym: CoBeN)

Investor: Evropská unie, Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Přiložené soubory

Elfmarkova_et_al_Neuropsychologia_2017_for_authors.pdf Verze souboru

Citovat

NĚMCOVÁ ELFMARKOVÁ, Nela; Martin GAJDOŠ; Irena REKTOROVÁ; Radek MAREČEK a Steven Z. RAPCSAK. Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease. Neuropsychologia. Oxford: Pergamon-Elsevier Science LTD, 2017, roč. 106, Nov 2017, s. 236-244. ISSN 0028-3932. Dostupné z: https://doi.org/10.1016/j.neuropsychologia.2017.09.034.

@article{1396986,
   author = {Němcová Elfmarková, Nela and Gajdoš, Martin and Rektorová, Irena and Mareček, Radek and Rapcsak, Steven Z.},
   article_location = {Oxford},
   article_number = {Nov 2017},
   doi = {https://doi.org/10.1016/j.neuropsychologia.2017.09.034},
   keywords = {Alzheimer's disease; fMRI; Mild cognitive impairment; Parkinson's disease; Top-down visual processing},
   language = {eng},
   issn = {0028-3932},
   journal = {Neuropsychologia},
   title = {Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease},
   volume = {106},
   year = {2017}
}

TY  - JOUR
ID  - 1396986
AU  - Němcová Elfmarková, Nela - Gajdoš, Martin - Rektorová, Irena - Mareček, Radek - Rapcsak, Steven Z.
PY  - 2017
TI  - Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease
JF  - Neuropsychologia
VL  - 106
IS  - Nov 2017
SP  - 236-244
EP  - 236-244
PB  - Pergamon-Elsevier Science LTD
SN  - 00283932
KW  - Alzheimer's disease
KW  - fMRI
KW  - Mild cognitive impairment
KW  - Parkinson's disease
KW  - Top-down visual processing
N2  - Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50% sensitivity and 86.98% specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.
ER  -

NĚMCOVÁ ELFMARKOVÁ, Nela; Martin GAJDOŠ; Irena REKTOROVÁ; Radek MAREČEK a Steven Z. RAPCSAK. Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease. \textit{Neuropsychologia}. Oxford: Pergamon-Elsevier Science LTD, 2017, roč.~106, Nov 2017, s.~236-244. ISSN~0028-3932. Dostupné z: https://doi.org/10.1016/j.neuropsychologia.2017.09.034.

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