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@article{1397254,
author = {Dražanová, Eva and Rudá, Jana and Kratka, Lucie and Horská, Kateřina and Demlová, Regina and Starčuk, Zenon and Kašpárek, Tomáš},
article_location = {Oxford},
article_number = {March 2018},
doi = {http://dx.doi.org/10.1016/j.brainresbull.2017.11.008},
keywords = {aripiprazole; Arterial Spin Labelling; Wistar rats; schizophrenia; sex; MRI},
language = {eng},
issn = {0361-9230},
journal = {Brain Research Bulletin},
title = {Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment},
url = {http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub},
volume = {137},
year = {2018}
}
TY - JOUR
ID - 1397254
AU - Dražanová, Eva - Rudá, Jana - Kratka, Lucie - Horská, Kateřina - Demlová, Regina - Starčuk, Zenon - Kašpárek, Tomáš
PY - 2018
TI - Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment
JF - Brain Research Bulletin
VL - 137
IS - March 2018
SP - 146-155
EP - 146-155
PB - Pergamon-Elsevier Science LTD
SN - 03619230
KW - aripiprazole
KW - Arterial Spin Labelling
KW - Wistar rats
KW - schizophrenia
KW - sex
KW - MRI
UR - http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub
L2 - http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub
N2 - ackground and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical antipsychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.
ER -
DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRATKA, Kateřina HORSKÁ, Regina DEMLOVÁ, Zenon STARČUK a Tomáš KAŠPÁREK. Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment. \textit{Brain Research Bulletin}. Oxford: Pergamon-Elsevier Science LTD, 2018, roč.~137, March 2018, s.~146-155. ISSN~0361-9230. Dostupné z: https://dx.doi.org/10.1016/j.brainresbull.2017.11.008.
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