Post-WBRT cognitive impairment and hippocampal neuronal
depletion measured by in vivo metabolic MR spectroscopy:
Results of prospective investigational study

J 2017

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

POSPÍŠIL, Petr; Tomáš KAZDA; Ludmila HYNKOVÁ; Martin BULIK; M. DOBIASKOVA et. al.

Základní údaje

Originální název

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

Autoři

POSPÍŠIL, Petr; Tomáš KAZDA; Ludmila HYNKOVÁ; Martin BULIK; M. DOBIASKOVA; Petr BURKOŇ; N.N. LAACK; Pavel ŠLAMPA a Radim JANČÁLEK

Vydání

Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology, Barcelona, Elsevier, 2017, 0167-8140

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.942

Kód RIV

RIV/00216224:14110/17:00098708

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.radonc.2016.12.013

UT WoS

000397691500008

EID Scopus

2-s2.0-85008496971

Klíčová slova anglicky

Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 18:07, Soňa Böhmová

Anotace

V originále

Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. Conclusions: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. 2016 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 122 (2017) 373-379

Citovat

POSPÍŠIL, Petr; Tomáš KAZDA; Ludmila HYNKOVÁ; Martin BULIK; M. DOBIASKOVA; Petr BURKOŇ; N.N. LAACK; Pavel ŠLAMPA a Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology. Barcelona: Elsevier, 2017, roč. 122, č. 3, s. 373-379. ISSN 0167-8140. Dostupné z: https://doi.org/10.1016/j.radonc.2016.12.013.

@article{1398895,
   author = {Pospíšil, Petr and Kazda, Tomáš and Hynková, Ludmila and Bulik, Martin and Dobiaskova, M. and Burkoň, Petr and Laack, N.N. and Šlampa, Pavel and Jančálek, Radim},
   article_location = {Barcelona},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.radonc.2016.12.013},
   keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
   language = {eng},
   issn = {0167-8140},
   journal = {Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology},
   title = {Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study},
   volume = {122},
   year = {2017}
}

TY  - JOUR
ID  - 1398895
AU  - Pospíšil, Petr - Kazda, Tomáš - Hynková, Ludmila - Bulik, Martin - Dobiaskova, M. - Burkoň, Petr - Laack, N.N. - Šlampa, Pavel - Jančálek, Radim
PY  - 2017
TI  - Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study
JF  - Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology
VL  - 122
IS  - 3
SP  - 373-379
EP  - 373-379
PB  - Elsevier
SN  - 01678140
KW  - Hippocampus
KW  - Radiation injury
KW  - Neurocognitive function
KW  - Magnetic resonance spectroscopy
N2  - Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. Conclusions: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. 2016 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 122 (2017) 373-379
ER  -

POSPÍŠIL, Petr; Tomáš KAZDA; Ludmila HYNKOVÁ; Martin BULIK; M. DOBIASKOVA; Petr BURKOŇ; N.N. LAACK; Pavel ŠLAMPA a Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. \textit{Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology}. Barcelona: Elsevier, 2017, roč.~122, č.~3, s.~373-379. ISSN~0167-8140. Dostupné z: https://doi.org/10.1016/j.radonc.2016.12.013.

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