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@article{1399112,
author = {Bienertová Vašků, Julie and Zlámal, Filip and Pohořalá, Aneta and Mikeš, Ondřej and Pávková Goldbergová, Monika and Novák, Jan and Šplíchal, Zbyněk and Pikhart, Hynek},
article_location = {ENGLAND},
article_number = {90},
doi = {http://dx.doi.org/10.1186/s12881-017-0454-z},
keywords = {VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure},
language = {eng},
issn = {1471-2350},
journal = {BMC Medical Genetics},
title = {Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population},
volume = {18},
year = {2017}
}
TY - JOUR
ID - 1399112
AU - Bienertová Vašků, Julie - Zlámal, Filip - Pohořalá, Aneta - Mikeš, Ondřej - Pávková Goldbergová, Monika - Novák, Jan - Šplíchal, Zbyněk - Pikhart, Hynek
PY - 2017
TI - Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
JF - BMC Medical Genetics
VL - 18
IS - 90
SP - 1-9
EP - 1-9
PB - BIOMED CENTRAL LTD
SN - 14712350
KW - VDR
KW - SNP
KW - Obesity
KW - Anthropometry
KW - Adiposity
KW - Gene
KW - Vitamin D
KW - Polymorphism
KW - Adiposity measure
N2 - Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej MIKEŠ, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL a Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. \textit{BMC Medical Genetics}. ENGLAND: BIOMED CENTRAL LTD, 2017, roč.~18, č.~90, s.~1-9. ISSN~1471-2350. Dostupné z: https://dx.doi.org/10.1186/s12881-017-0454-z.
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