Allelic variants in vitamin D receptor gene are associated with
adiposity measures in the central-European population

J 2017

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

BIENERTOVÁ VAŠKŮ, Julie; Filip ZLÁMAL; Aneta POHOŘALÁ; Ondřej MIKEŠ; Monika PÁVKOVÁ GOLDBERGOVÁ et. al.

Základní údaje

Originální název

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

Autoři

BIENERTOVÁ VAŠKŮ, Julie; Filip ZLÁMAL ; Aneta POHOŘALÁ; Ondřej MIKEŠ; Monika PÁVKOVÁ GOLDBERGOVÁ; Jan NOVÁK; Zbyněk ŠPLÍCHAL a Hynek PIKHART

Vydání

BMC Medical Genetics, ENGLAND, BIOMED CENTRAL LTD, 2017, 1471-2350

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.913

Kód RIV

RIV/00216224:14110/17:00098762

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/s12881-017-0454-z

UT WoS

000408145600001

EID Scopus

2-s2.0-85028036884

Klíčová slova anglicky

VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2018 16:04, Soňa Böhmová

Anotace

V originále

Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

BIENERTOVÁ VAŠKŮ, Julie; Filip ZLÁMAL; Aneta POHOŘALÁ; Ondřej MIKEŠ; Monika PÁVKOVÁ GOLDBERGOVÁ; Jan NOVÁK; Zbyněk ŠPLÍCHAL a Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. BMC Medical Genetics. ENGLAND: BIOMED CENTRAL LTD, 2017, roč. 18, č. 90, s. 1-9. ISSN 1471-2350. Dostupné z: https://doi.org/10.1186/s12881-017-0454-z.

@article{1399112,
   author = {Bienertová Vašků, Julie and Zlámal, Filip and Pohořalá, Aneta and Mikeš, Ondřej and Pávková Goldbergová, Monika and Novák, Jan and Šplíchal, Zbyněk and Pikhart, Hynek},
   article_location = {ENGLAND},
   article_number = {90},
   doi = {https://doi.org/10.1186/s12881-017-0454-z},
   keywords = {VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure},
   language = {eng},
   issn = {1471-2350},
   journal = {BMC Medical Genetics},
   title = {Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population},
   volume = {18},
   year = {2017}
}

TY  - JOUR
ID  - 1399112
AU  - Bienertová Vašků, Julie - Zlámal, Filip - Pohořalá, Aneta - Mikeš, Ondřej - Pávková Goldbergová, Monika - Novák, Jan - Šplíchal, Zbyněk - Pikhart, Hynek
PY  - 2017
TI  - Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
JF  - BMC Medical Genetics
VL  - 18
IS  - 90
SP  - 1-9
EP  - 1-9
PB  - BIOMED CENTRAL LTD
SN  - 14712350
KW  - VDR
KW  - SNP
KW  - Obesity
KW  - Anthropometry
KW  - Adiposity
KW  - Gene
KW  - Vitamin D
KW  - Polymorphism
KW  - Adiposity measure
N2  - Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
ER  -

BIENERTOVÁ VAŠKŮ, Julie; Filip ZLÁMAL; Aneta POHOŘALÁ; Ondřej MIKEŠ; Monika PÁVKOVÁ GOLDBERGOVÁ; Jan NOVÁK; Zbyněk ŠPLÍCHAL a Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. \textit{BMC Medical Genetics}. ENGLAND: BIOMED CENTRAL LTD, 2017, roč.~18, č.~90, s.~1-9. ISSN~1471-2350. Dostupné z: https://doi.org/10.1186/s12881-017-0454-z.

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